Beside the MEF2 axis: Unconventional functions of HDAC4

The class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF...

Full description

Saved in:
Bibliographic Details
Published in:Cellular signalling 2013-01, Vol.25 (1), p.269-276
Main Authors: Clocchiatti, Andrea, Di Giorgio, Eros, Demarchi, Francesca, Brancolini, Claudio
Format: Article
Language:English
Subjects:
Basic Helix-Loop-Helix Transcription Factors - metabolism
Cellular
Forkhead Transcription Factors - metabolism
FOXOs
Foxp3
HIF
Histone deacetylase
Histone Deacetylases - metabolism
Humans
LXB
MEF2
Metabolism
Muscle
Myogenic Regulatory Factors - genetics
Myogenic Regulatory Factors - metabolism
Protein Binding
Regulators
Repressor Proteins - metabolism
Signalling
STAT1
STAT1 Transcription Factor - metabolism
Sumoylation
Transcription, Genetic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF2s. At the same time, pieces of evidence have gradually accumulated about HDAC4 activities emancipated from MEF2s. The aim of this review is to discuss about these “unconventional functions” of HDAC4. ► HDAC4 and class IIa HDACs are key regulators of MEF2 transcriptional activities. ► Several data in the literature point to additional transcriptional partners of HDAC4. ► We have discussed about recent data on these “unconventional” class IIa HDAC partners.
ISSN:0898-6568
1873-3913
DOI:10.1016/j.cellsig.2012.10.002