Catalytic Oxidation of C(sp3)H Bonds Induced by a Radical Cation Salt: Construction of 1,4-Dihydropyridines Using a Fragment-Reassembly Strategy

A fragment‐reassembly strategy was applied to the construction of 1,4‐dihydropyridines and phosphorus‐substituted 1,4‐dihydropyridines under catalytic radical cation salt‐induced C(sp)3H functionalization of glycine derivatives. Mechanistic studies show that domino C(sp)3H bond oxidation and CN b...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2014-04, Vol.356 (6), p.1210-1216
Main Authors: Jia, Xiaodong, Wang, Yaxin, Peng, Fangfang, Huo, Congde, Yu, Liangling, Liu, Jing, Wang, Xicun
Format: Article
Language:English
Subjects:
1,4‐dihydropyridines
4-dihydropyridines
Catalysis
Catalysts
Cations
Construction
CH oxidation
CN cleavage
fragment-reassembly strategy
Fragmentation
Oxidation
radical cation salts
Radicals
Strategy
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Summary:A fragment‐reassembly strategy was applied to the construction of 1,4‐dihydropyridines and phosphorus‐substituted 1,4‐dihydropyridines under catalytic radical cation salt‐induced C(sp)3H functionalization of glycine derivatives. Mechanistic studies show that domino C(sp)3H bond oxidation and CN bond cleavage reactions are involved.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201300810