Analyser-based x-ray imaging for biomedical research

Analyser-based imaging (ABI) is one of the several phase-contrast x-ray imaging techniques being pursued at synchrotron radiation facilities. With advancements in compact source technology, there is a possibility that ABI will become a clinical imaging modality. This paper presents the history of AB...

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Bibliographic Details
Published in:Journal of physics. D, Applied physics Applied physics, 2013-12, Vol.46 (49), p.494002-25
Main Authors: Suortti, Pekka, Keyriläinen, Jani, Thomlinson, William
Format: Article
Language:English
Subjects:
Algorithms
Bones
Breast
Imaging
Monochromators
Synchrotron radiation
Synchrotrons
X-rays
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Summary:Analyser-based imaging (ABI) is one of the several phase-contrast x-ray imaging techniques being pursued at synchrotron radiation facilities. With advancements in compact source technology, there is a possibility that ABI will become a clinical imaging modality. This paper presents the history of ABI as it has developed from its laboratory source to synchrotron imaging. The fundamental physics of phase-contrast imaging is presented both in a general sense and specifically for ABI. The technology is dependent on the use of perfect crystal monochromator optics. The theory of the x-ray optics is developed and presented in a way that will allow optimization of the imaging for specific biomedical systems. The advancement of analytical algorithms to produce separate images of the sample absorption, refraction angle map and small-angle x-ray scattering is detailed. Several detailed applications to biomedical imaging are presented to illustrate the broad range of systems and body sites studied preclinically to date: breast, cartilage and bone, soft tissue and organs. Ultimately, the application of ABI in clinical imaging will depend partly on the availability of compact sources with sufficient x-ray intensity comparable with that of the current synchrotron environment.
ISSN:0022-3727
1361-6463
DOI:10.1088/0022-3727/46/49/494002