Detection of Single Nanoparticles and Lentiviruses Using Microcavity Resonance Broadening

A new label‐free sensing mechanism is demonstrated experimentally by monitoring the whispering‐gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra‐high‐Q mode cavities for sen...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2013-10, Vol.25 (39), p.5616-5620
Main Authors: Shao, Linbo, Jiang, Xue-Feng, Yu, Xiao-Chong, Li, Bei-Bei, Clements, William R., Vollmer, Frank, Wang, Wei, Xiao, Yun-Feng, Gong, Qihuang
Format: Article
Language:English
Subjects:
Environmental monitoring
Holes
label-free biosensing
Lasers
Lentivirus
Lentivirus - isolation & purification
Microcavities
microcavity mode broadening
Microtechnology - methods
Nanocomposites
Nanomaterials
nanoparticle detection
Nanoparticles
Nanoparticles - analysis
Nanostructure
rayleigh scattering
whispering gallery mode
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new label‐free sensing mechanism is demonstrated experimentally by monitoring the whispering‐gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra‐high‐Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma201302572