Multi-modality imaging findings of methotrexate-related Epstein–Barr virus-associated hepatic tumor

Abstract Methotrexate (MTX)-associated lymphoproliferative disorders (MTX-LPDs) that occur in rheumatoid arthritis patients who were administered MTX for long periods are well known. However, studies on their pathology in forming hepatic tumors are rare. An approach using diagnostic imaging modaliti...

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Bibliographic Details
Published in:Clinical imaging 2013-09, Vol.37 (5), p.962-964
Main Authors: Fujita, Takeshi, Tanabe, Masahiro, Iida, Etsushi, Okimoto, Tomoaki, Matsunaga, Naofumi
Format: Article
Language:English
Subjects:
Abdomen
Aged
Antirheumatic Agents - adverse effects
Antirheumatic Agents - therapeutic use
Arthritis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
computed tomography
Diagnosis, Differential
Dynamic tests
Epstein-Barr virus
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - drug therapy
Epstein-Barr Virus Infections - etiology
Family medical history
Hepatic tumor
Herpesvirus 4, Human
Humans
Imaging
Immunosuppressive Agents - adverse effects
Infections
Liver cancer
Liver Neoplasms - diagnosis
Liver Neoplasms - drug therapy
Liver Neoplasms - virology
Lymphoma - diagnosis
Lymphoma - drug therapy
Lymphoma - virology
Male
Medical imaging
Methotrexate
Methotrexate - adverse effects
Methotrexate - therapeutic use
Multimodal Imaging
Pathology
Patients
Radiology
Tomography
Transplants & implants
Tumors
Ultrasonic imaging
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Description
Summary:Abstract Methotrexate (MTX)-associated lymphoproliferative disorders (MTX-LPDs) that occur in rheumatoid arthritis patients who were administered MTX for long periods are well known. However, studies on their pathology in forming hepatic tumors are rare. An approach using diagnostic imaging modalities, mainly computed tomography (CT), is considered a very useful tool for the differential diagnosis of various hepatic tumors. In the present study, detailed findings of dynamic CT, magnetic resonance (MR) imaging, and contrast-enhanced ultrasonography of a hepatic tumor that was confirmed as infected by Epstein–Barr virus, in a rheumatoid arthritis patient administered MTX are presented.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2013.05.005