Synthesis, structural characterization, cytotoxicity in vitro, and effect on DNA of sulfate-trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV)

• Published in: Journal of molecular structure 2014, Vol.1058, p.9-13
• Main Authors: Jiménez-Pérez, Víctor M., Muñoz-Flores, Blanca M., Gómez, Alberto, Kharisov, Boris, Santillan, Rosa, Ochoa, María E., Blanco Jerez, Leonor M., García, Concepción, Waksman, Noemí, Ramírez, Rosalba
• Format: Article
• Language: English
• Subjects: Biological; Deoxyribonucleic acid; Derivatives; DNA interaction; Molecular structure; Organotin; Organotin compounds; Single crystals; Sulfate; Sulfates; Tin; X-ray
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2013.10.013

•Synthesis and X-ray structural characterization of trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV).•Organotin interaction with DNA at 95°C and low cytotoxicity.•The crystal structure has a polymeric arrangement with eight-membered rings as a result of intermolecular coordination SO→Sn. The trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV) resulted from the reaction of dimethyl-tin(IV) dichloride and sodium sulfate in dimethylsulfoxide (DMSO). The tin compound was characterized by IR, NMR, FE-SEM, EDS, and single crystal X-ray diffraction studies. Suitable DMSO single crystals were obtained after 7months by slow evaporation at room temperature. The crystal structure has a polymeric arrangement with eight-membered rings as a result of intermolecular coordination SO→Sn. The tin atom has an octahedral distorted geometry where the DMSO molecule is coordinated, and also has an infinite arrangement in 2D. Cytotoxicity against A431 cancer cells and MOLT4 leukemic cells and the DNA interaction of the organotin compound were determined. The organotin sulfate derivative showed low biological activity because of the polymeric structure and the saturated tin coordination capability.