Characterization of C sub(60) fullerene complexation with antibiotic doxorubicin

The aim of this paper was to provide the physico-chemical characterization of a key process leading to amplification of the antitumor effect of antibiotic Doxorubicin (Dox) in vivoand in vitroand occurring at the molecular level through complexation with C sub(60) fullerene. A wide range of physico-...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2014-10, Vol.16 (42), p.23164-23172
Main Authors: Prylutskyy, YuI, Evstigneev, M P, Pashkova, I S, Wyrzykowski, D, Woziwodzka, A, Golunski, G, Piosik, J, Cherepanov, V V, Ritter, U
Format: Article
Language:English
Subjects:
Antibiotics
Binding
Buckminsterfullerene
Complexation
Doxorubicin
Fullerenes
NMR spectroscopy
Titration calorimetry
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Summary:The aim of this paper was to provide the physico-chemical characterization of a key process leading to amplification of the antitumor effect of antibiotic Doxorubicin (Dox) in vivoand in vitroand occurring at the molecular level through complexation with C sub(60) fullerene. A wide range of physico-chemical tools was used such as UV/Vis and NMR spectroscopies, atomic force microscopy, isothermal titration calorimetry and zeta-potential methods. The unusual thermodynamic behavior of the complexation process was reported, featuring unexpected and, to a certain extent, contradictory experimental observations. The explanation of the obtained results was proposed resulting in creation of a general view on aromatic drug binding with C sub(60) fullerene. Based on these results some important practical outcomes for anticancer therapy were formulated.
ISSN:1463-9076
1463-9084
DOI:10.1039/c4cp03367a