Unraveling Stress-Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism

Graphene oxide shows stress‐induced toxicity properties in vivo under different pathophysiological conditions. A dual‐path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2012-10, Vol.24 (39), p.5391-5397
Main Authors: Zhang, Wendi, Wang, Chi, Li, Zhongjun, Lu, Zhenzhen, Li, Yiye, Yin, Jun-Jie, Zhou, Yu-Ting, Gao, Xingfa, Fang, Ying, Nie, Guangjun, Zhao, Yuliang
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biomedical materials
Caenorhabditis elegans - drug effects
Caenorhabditis elegans - metabolism
Cyclic N-Oxides - chemistry
electron transfer
functional materials
Graphene
graphene oxide
Graphite - chemistry
Graphite - toxicity
Hydroxyl radicals
In vivo testing
In vivo tests
Nanostructures - toxicity
nanotoxicity
Oxidative Stress
Oxides
Oxides - chemistry
Oxides - toxicity
Polyethylene Glycols - chemistry
Polylysine - chemistry
Toxicity
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Description
Summary:Graphene oxide shows stress‐induced toxicity properties in vivo under different pathophysiological conditions. A dual‐path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201202678