Loading…

Micromorphology analysis and bond strength of two adhesives to Er,Cr:YSGG laser-prepared vs. Bur-prepared fluorosed enamel

ABSTRACT Preservation of enamel during composite veneer restorations of fluorosed teeth could be achieved by conservative preparation with Erbium lasers. This study evaluated the effect of fluorosed enamel preparation with Er,Cr:YSGG vs. conventional diamond bur on the micromorphology and bond stren...

Full description

Saved in:
Bibliographic Details
Published in:Microscopy research and technique 2014-10, Vol.77 (10), p.779-784
Main Authors: Shafiei, Fereshteh, JOWKAR, Zahra, Fekrazad, Reza, Khalafi-nezhad, Abolfazl
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4289-f895a34ceefd2f89856fc20abb73b97cdaecb521399b6f433f011b717cb552333
cites cdi_FETCH-LOGICAL-c4289-f895a34ceefd2f89856fc20abb73b97cdaecb521399b6f433f011b717cb552333
container_end_page 784
container_issue 10
container_start_page 779
container_title Microscopy research and technique
container_volume 77
creator Shafiei, Fereshteh
JOWKAR, Zahra
Fekrazad, Reza
Khalafi-nezhad, Abolfazl
description ABSTRACT Preservation of enamel during composite veneer restorations of fluorosed teeth could be achieved by conservative preparation with Erbium lasers. This study evaluated the effect of fluorosed enamel preparation with Er,Cr:YSGG vs. conventional diamond bur on the micromorphology and bond strength of a self‐etch and an etch‐and‐rinse adhesives. Er,Cr:YSGG laser or diamond bur preparation was performed on the flattened midbuccal surfaces of 70 extracted human premolars with moderate fluorosis (according to Thylstrup and Fejerskov index, TFI = 4–6). Adper Single Bond (SB) with acid etching for 20 or 40 s and Clearfil SE Bond (SEB) alone or with additional etching was applied in four laser groups. The same adhesive procedures were used in three bur groups except for 40 s of etching along with SB. After restoration, microshear bond strength was measured (MPa). Data were analyzed using ANOVA and Tamhane tests (α = 0.05). Six additional specimens were differently prepared and conditioned for scanning electron microscopy evaluation. The highest and lowest bond strengths were obtained for bur‐prepared/SB (39.5) and laser‐prepared/SEB (16.9), respectively, with a significant difference (P = 0.001). The different adhesive procedures used associated to two adhesives exhibited insignificantly lower bonding in laser‐prepared groups compared to bur‐prepared ones (P > 0.05), with the exception of additional etching/SEB, which bonded significantly higher to bur‐prepared (36.4) than to laser‐prepared enamel (18.7, P = 0.04). Morphological analyses revealed a delicate etch pattern with exposed enamel prisms on laser‐prepared fluorosed enamel after acid etching and less microretentive pattern after self‐etching primer. The etch‐and‐rinse adhesive was preferred in the laser‐prepared fluorosed enamel in terms of bonding performance. Microsc. Res. Tech. 77:779–784, 2014. © 2014 Wiley Periodicals, Inc.
doi_str_mv 10.1002/jemt.22399
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1671570362</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1671570362</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4289-f895a34ceefd2f89856fc20abb73b97cdaecb521399b6f433f011b717cb552333</originalsourceid><addsrcrecordid>eNqFkUtvEzEUhS0EoqWw4QcgS2wqxAQ_xzG7EoUEaMqiRTw2lmfmupkwEw_2TEv66-s0bYVYwMa-Pv7uke49CD2nZEQJYW9W0PYjxrjWD9A-JVplSdUPt7XUmabk2x56EuOKEEolFY_RHpNEiPS5j64WdRl860O39I0_32C7ts0m1jEVFS58OmIfYH3eL7F3uL_02FZLiPUFRNx7PA2vJ-Ht99PZDDc2Qsi6AJ0NUOGLOMLvhj8E1ww--JgqWNsWmqfokbNNhGe39wH68n56Nplnx59nHyZHx1kp2Fhnbqyl5aIEcBVLj7HMXcmILQrFC63KykJZSEbT-EXuBOcujVkoqpIqGef8AB3ufLvgfw0Qe9PWsYSmsWvwQzQ0V1QqwnP2f1TmTAgqxNb15V_oyg8hLe-GojnhSqhEvdpRackxBnCmC3Vrw8ZQYrbhmW145ia8BL-4tRyKFqp79C6tBNAdcFk3sPmHlfk4XZzdmWa7njr28Pu-x4afJldcSfP1ZGZO5hM2P_3xySz4NT31tAc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1561603747</pqid></control><display><type>article</type><title>Micromorphology analysis and bond strength of two adhesives to Er,Cr:YSGG laser-prepared vs. Bur-prepared fluorosed enamel</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Shafiei, Fereshteh ; JOWKAR, Zahra ; Fekrazad, Reza ; Khalafi-nezhad, Abolfazl</creator><creatorcontrib>Shafiei, Fereshteh ; JOWKAR, Zahra ; Fekrazad, Reza ; Khalafi-nezhad, Abolfazl</creatorcontrib><description>ABSTRACT Preservation of enamel during composite veneer restorations of fluorosed teeth could be achieved by conservative preparation with Erbium lasers. This study evaluated the effect of fluorosed enamel preparation with Er,Cr:YSGG vs. conventional diamond bur on the micromorphology and bond strength of a self‐etch and an etch‐and‐rinse adhesives. Er,Cr:YSGG laser or diamond bur preparation was performed on the flattened midbuccal surfaces of 70 extracted human premolars with moderate fluorosis (according to Thylstrup and Fejerskov index, TFI = 4–6). Adper Single Bond (SB) with acid etching for 20 or 40 s and Clearfil SE Bond (SEB) alone or with additional etching was applied in four laser groups. The same adhesive procedures were used in three bur groups except for 40 s of etching along with SB. After restoration, microshear bond strength was measured (MPa). Data were analyzed using ANOVA and Tamhane tests (α = 0.05). Six additional specimens were differently prepared and conditioned for scanning electron microscopy evaluation. The highest and lowest bond strengths were obtained for bur‐prepared/SB (39.5) and laser‐prepared/SEB (16.9), respectively, with a significant difference (P = 0.001). The different adhesive procedures used associated to two adhesives exhibited insignificantly lower bonding in laser‐prepared groups compared to bur‐prepared ones (P &gt; 0.05), with the exception of additional etching/SEB, which bonded significantly higher to bur‐prepared (36.4) than to laser‐prepared enamel (18.7, P = 0.04). Morphological analyses revealed a delicate etch pattern with exposed enamel prisms on laser‐prepared fluorosed enamel after acid etching and less microretentive pattern after self‐etching primer. The etch‐and‐rinse adhesive was preferred in the laser‐prepared fluorosed enamel in terms of bonding performance. Microsc. Res. Tech. 77:779–784, 2014. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 1059-910X</identifier><identifier>EISSN: 1097-0029</identifier><identifier>DOI: 10.1002/jemt.22399</identifier><identifier>PMID: 25044059</identifier><identifier>CODEN: MRTEEO</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>acid etching ; Adhesives ; Adult ; Analysis of variance ; bond strength ; Bonding ; Bonding strength ; Composite Resins - chemistry ; Composite Resins - therapeutic use ; Cr:YSGG laser ; Dental Bonding ; Dental Cements - chemistry ; Dental Cements - therapeutic use ; Dental Enamel - ultrastructure ; Dental Stress Analysis ; Enamels ; Er,Cr:YSGG laser ; Etching ; fluorosed enamel ; Fluorosis, Dental - pathology ; Humans ; Lasers ; Microscopy, Electron, Scanning ; Resin Cements - chemistry ; Resin Cements - therapeutic use ; Restoration ; scanning electron microscopy ; Young Adult</subject><ispartof>Microscopy research and technique, 2014-10, Vol.77 (10), p.779-784</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4289-f895a34ceefd2f89856fc20abb73b97cdaecb521399b6f433f011b717cb552333</citedby><cites>FETCH-LOGICAL-c4289-f895a34ceefd2f89856fc20abb73b97cdaecb521399b6f433f011b717cb552333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25044059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shafiei, Fereshteh</creatorcontrib><creatorcontrib>JOWKAR, Zahra</creatorcontrib><creatorcontrib>Fekrazad, Reza</creatorcontrib><creatorcontrib>Khalafi-nezhad, Abolfazl</creatorcontrib><title>Micromorphology analysis and bond strength of two adhesives to Er,Cr:YSGG laser-prepared vs. Bur-prepared fluorosed enamel</title><title>Microscopy research and technique</title><addtitle>Microsc. Res. Tech</addtitle><description>ABSTRACT Preservation of enamel during composite veneer restorations of fluorosed teeth could be achieved by conservative preparation with Erbium lasers. This study evaluated the effect of fluorosed enamel preparation with Er,Cr:YSGG vs. conventional diamond bur on the micromorphology and bond strength of a self‐etch and an etch‐and‐rinse adhesives. Er,Cr:YSGG laser or diamond bur preparation was performed on the flattened midbuccal surfaces of 70 extracted human premolars with moderate fluorosis (according to Thylstrup and Fejerskov index, TFI = 4–6). Adper Single Bond (SB) with acid etching for 20 or 40 s and Clearfil SE Bond (SEB) alone or with additional etching was applied in four laser groups. The same adhesive procedures were used in three bur groups except for 40 s of etching along with SB. After restoration, microshear bond strength was measured (MPa). Data were analyzed using ANOVA and Tamhane tests (α = 0.05). Six additional specimens were differently prepared and conditioned for scanning electron microscopy evaluation. The highest and lowest bond strengths were obtained for bur‐prepared/SB (39.5) and laser‐prepared/SEB (16.9), respectively, with a significant difference (P = 0.001). The different adhesive procedures used associated to two adhesives exhibited insignificantly lower bonding in laser‐prepared groups compared to bur‐prepared ones (P &gt; 0.05), with the exception of additional etching/SEB, which bonded significantly higher to bur‐prepared (36.4) than to laser‐prepared enamel (18.7, P = 0.04). Morphological analyses revealed a delicate etch pattern with exposed enamel prisms on laser‐prepared fluorosed enamel after acid etching and less microretentive pattern after self‐etching primer. The etch‐and‐rinse adhesive was preferred in the laser‐prepared fluorosed enamel in terms of bonding performance. Microsc. Res. Tech. 77:779–784, 2014. © 2014 Wiley Periodicals, Inc.</description><subject>acid etching</subject><subject>Adhesives</subject><subject>Adult</subject><subject>Analysis of variance</subject><subject>bond strength</subject><subject>Bonding</subject><subject>Bonding strength</subject><subject>Composite Resins - chemistry</subject><subject>Composite Resins - therapeutic use</subject><subject>Cr:YSGG laser</subject><subject>Dental Bonding</subject><subject>Dental Cements - chemistry</subject><subject>Dental Cements - therapeutic use</subject><subject>Dental Enamel - ultrastructure</subject><subject>Dental Stress Analysis</subject><subject>Enamels</subject><subject>Er,Cr:YSGG laser</subject><subject>Etching</subject><subject>fluorosed enamel</subject><subject>Fluorosis, Dental - pathology</subject><subject>Humans</subject><subject>Lasers</subject><subject>Microscopy, Electron, Scanning</subject><subject>Resin Cements - chemistry</subject><subject>Resin Cements - therapeutic use</subject><subject>Restoration</subject><subject>scanning electron microscopy</subject><subject>Young Adult</subject><issn>1059-910X</issn><issn>1097-0029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkUtvEzEUhS0EoqWw4QcgS2wqxAQ_xzG7EoUEaMqiRTw2lmfmupkwEw_2TEv66-s0bYVYwMa-Pv7uke49CD2nZEQJYW9W0PYjxrjWD9A-JVplSdUPt7XUmabk2x56EuOKEEolFY_RHpNEiPS5j64WdRl860O39I0_32C7ts0m1jEVFS58OmIfYH3eL7F3uL_02FZLiPUFRNx7PA2vJ-Ht99PZDDc2Qsi6AJ0NUOGLOMLvhj8E1ww--JgqWNsWmqfokbNNhGe39wH68n56Nplnx59nHyZHx1kp2Fhnbqyl5aIEcBVLj7HMXcmILQrFC63KykJZSEbT-EXuBOcujVkoqpIqGef8AB3ufLvgfw0Qe9PWsYSmsWvwQzQ0V1QqwnP2f1TmTAgqxNb15V_oyg8hLe-GojnhSqhEvdpRackxBnCmC3Vrw8ZQYrbhmW145ia8BL-4tRyKFqp79C6tBNAdcFk3sPmHlfk4XZzdmWa7njr28Pu-x4afJldcSfP1ZGZO5hM2P_3xySz4NT31tAc</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Shafiei, Fereshteh</creator><creator>JOWKAR, Zahra</creator><creator>Fekrazad, Reza</creator><creator>Khalafi-nezhad, Abolfazl</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Micromorphology analysis and bond strength of two adhesives to Er,Cr:YSGG laser-prepared vs. Bur-prepared fluorosed enamel</title><author>Shafiei, Fereshteh ; JOWKAR, Zahra ; Fekrazad, Reza ; Khalafi-nezhad, Abolfazl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4289-f895a34ceefd2f89856fc20abb73b97cdaecb521399b6f433f011b717cb552333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>acid etching</topic><topic>Adhesives</topic><topic>Adult</topic><topic>Analysis of variance</topic><topic>bond strength</topic><topic>Bonding</topic><topic>Bonding strength</topic><topic>Composite Resins - chemistry</topic><topic>Composite Resins - therapeutic use</topic><topic>Cr:YSGG laser</topic><topic>Dental Bonding</topic><topic>Dental Cements - chemistry</topic><topic>Dental Cements - therapeutic use</topic><topic>Dental Enamel - ultrastructure</topic><topic>Dental Stress Analysis</topic><topic>Enamels</topic><topic>Er,Cr:YSGG laser</topic><topic>Etching</topic><topic>fluorosed enamel</topic><topic>Fluorosis, Dental - pathology</topic><topic>Humans</topic><topic>Lasers</topic><topic>Microscopy, Electron, Scanning</topic><topic>Resin Cements - chemistry</topic><topic>Resin Cements - therapeutic use</topic><topic>Restoration</topic><topic>scanning electron microscopy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shafiei, Fereshteh</creatorcontrib><creatorcontrib>JOWKAR, Zahra</creatorcontrib><creatorcontrib>Fekrazad, Reza</creatorcontrib><creatorcontrib>Khalafi-nezhad, Abolfazl</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microscopy research and technique</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shafiei, Fereshteh</au><au>JOWKAR, Zahra</au><au>Fekrazad, Reza</au><au>Khalafi-nezhad, Abolfazl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micromorphology analysis and bond strength of two adhesives to Er,Cr:YSGG laser-prepared vs. Bur-prepared fluorosed enamel</atitle><jtitle>Microscopy research and technique</jtitle><addtitle>Microsc. Res. Tech</addtitle><date>2014-10</date><risdate>2014</risdate><volume>77</volume><issue>10</issue><spage>779</spage><epage>784</epage><pages>779-784</pages><issn>1059-910X</issn><eissn>1097-0029</eissn><coden>MRTEEO</coden><abstract>ABSTRACT Preservation of enamel during composite veneer restorations of fluorosed teeth could be achieved by conservative preparation with Erbium lasers. This study evaluated the effect of fluorosed enamel preparation with Er,Cr:YSGG vs. conventional diamond bur on the micromorphology and bond strength of a self‐etch and an etch‐and‐rinse adhesives. Er,Cr:YSGG laser or diamond bur preparation was performed on the flattened midbuccal surfaces of 70 extracted human premolars with moderate fluorosis (according to Thylstrup and Fejerskov index, TFI = 4–6). Adper Single Bond (SB) with acid etching for 20 or 40 s and Clearfil SE Bond (SEB) alone or with additional etching was applied in four laser groups. The same adhesive procedures were used in three bur groups except for 40 s of etching along with SB. After restoration, microshear bond strength was measured (MPa). Data were analyzed using ANOVA and Tamhane tests (α = 0.05). Six additional specimens were differently prepared and conditioned for scanning electron microscopy evaluation. The highest and lowest bond strengths were obtained for bur‐prepared/SB (39.5) and laser‐prepared/SEB (16.9), respectively, with a significant difference (P = 0.001). The different adhesive procedures used associated to two adhesives exhibited insignificantly lower bonding in laser‐prepared groups compared to bur‐prepared ones (P &gt; 0.05), with the exception of additional etching/SEB, which bonded significantly higher to bur‐prepared (36.4) than to laser‐prepared enamel (18.7, P = 0.04). Morphological analyses revealed a delicate etch pattern with exposed enamel prisms on laser‐prepared fluorosed enamel after acid etching and less microretentive pattern after self‐etching primer. The etch‐and‐rinse adhesive was preferred in the laser‐prepared fluorosed enamel in terms of bonding performance. Microsc. Res. Tech. 77:779–784, 2014. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25044059</pmid><doi>10.1002/jemt.22399</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1059-910X
ispartof Microscopy research and technique, 2014-10, Vol.77 (10), p.779-784
issn 1059-910X
1097-0029
language eng
recordid cdi_proquest_miscellaneous_1671570362
source Wiley-Blackwell Read & Publish Collection
subjects acid etching
Adhesives
Adult
Analysis of variance
bond strength
Bonding
Bonding strength
Composite Resins - chemistry
Composite Resins - therapeutic use
Cr:YSGG laser
Dental Bonding
Dental Cements - chemistry
Dental Cements - therapeutic use
Dental Enamel - ultrastructure
Dental Stress Analysis
Enamels
Er,Cr:YSGG laser
Etching
fluorosed enamel
Fluorosis, Dental - pathology
Humans
Lasers
Microscopy, Electron, Scanning
Resin Cements - chemistry
Resin Cements - therapeutic use
Restoration
scanning electron microscopy
Young Adult
title Micromorphology analysis and bond strength of two adhesives to Er,Cr:YSGG laser-prepared vs. Bur-prepared fluorosed enamel
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T22%3A09%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Micromorphology%20analysis%20and%20bond%20strength%20of%20two%20adhesives%20to%20Er,Cr:YSGG%20laser-prepared%20vs.%20Bur-prepared%20fluorosed%20enamel&rft.jtitle=Microscopy%20research%20and%20technique&rft.au=Shafiei,%20Fereshteh&rft.date=2014-10&rft.volume=77&rft.issue=10&rft.spage=779&rft.epage=784&rft.pages=779-784&rft.issn=1059-910X&rft.eissn=1097-0029&rft.coden=MRTEEO&rft_id=info:doi/10.1002/jemt.22399&rft_dat=%3Cproquest_cross%3E1671570362%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4289-f895a34ceefd2f89856fc20abb73b97cdaecb521399b6f433f011b717cb552333%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1561603747&rft_id=info:pmid/25044059&rfr_iscdi=true