Photo-crosslinkable PEG-Based Microribbons for Forming 3D Macroporous Scaffolds with Decoupled Niche Properties

PEG‐based microribbons are designed and fabricated as building blocks for constructing a 3D cell niche with independently tunable biochemical, mechanical, and topographical cues. This platform supports direct cell encapsulation, allows spatial patterning of biochemical cues, and may provide a valuab...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2014-03, Vol.26 (11), p.1757-1762
Main Authors: Han, Li-Hsin, Tong, Xinming, Yang, Fan
Format: Article
Language:English
Subjects:
Adipose Tissue - cytology
Adipose Tissue - physiology
Biochemistry
Biocompatible Materials - chemistry
biomedical applications
Cell Movement - physiology
Cell Proliferation
Cues
Cystine - chemistry
Elasticity
Encapsulation
Humans
Hydrogels - chemistry
Interactive
microribbons
Microscopy, Confocal
Microtechnology
Patterning
Peptides - metabolism
Platforms
Polyethylene Glycols - chemistry
Porosity
scaffolds
Signal Transduction
Stromal Cells - cytology
Stromal Cells - physiology
Surface Properties
Three dimensional
tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Description
Summary:PEG‐based microribbons are designed and fabricated as building blocks for constructing a 3D cell niche with independently tunable biochemical, mechanical, and topographical cues. This platform supports direct cell encapsulation, allows spatial patterning of biochemical cues, and may provide a valuable tool for facilitating the analyses of how interactive niche signaling regulates cell fate in three dimensions.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201304805