Poly(L-histidine)-chitosan/alginate complex microcapsule as a novel drug delivery agent

Novel poly(L‐histidine)‐chitosan/alginate complex microcapsules were prepared from biodegradable polymers poly(L‐histidine) (PLHis) in the presence of chitosan at acetate buffer solution pH 4.6. Microcapsules obtained are spherical and well‐dispersed with a smooth surface and a narrow size distribut...

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Bibliographic Details
Published in:Journal of applied polymer science 2012-06, Vol.124 (5), p.3728-3736
Main Authors: Chen, Ai-Zheng, Chen, Mei-Ying, Wang, Shi-Bin, Huang, Xiao-Nan, Liu, Yuan-Gang, Chen, Zong-Xiang
Format: Article
Language:English
Subjects:
alginate
Alginates
Applied sciences
Biodegradability
Biological and medical sciences
Chitosan
controlled release
Drugs
Encapsulation
Exact sciences and technology
Forms of application and semi-finished materials
General pharmacology
Hemoglobin
Materials science
Medical sciences
microcapsules
Miscellaneous
Molecular weight
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
poly(amino acid)
Polymer industry, paints, wood
Polymers
Proteins
Technology of polymers
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Summary:Novel poly(L‐histidine)‐chitosan/alginate complex microcapsules were prepared from biodegradable polymers poly(L‐histidine) (PLHis) in the presence of chitosan at acetate buffer solution pH 4.6. Microcapsules obtained are spherical and well‐dispersed with a smooth surface and a narrow size distribution. The microcapsules can encapsulate the protein model drug hemoglobin (Hb) efficiently. The results show that the complex microcapsules with low, medium, or high molecular weight of chitosan (0.05%, w/v), the highest encapsulation efficiencies obtained are 91.3%, 85.9%, and 94.2% with loading efficiencies of 47.8%, 44.3%, and 39.7%, respectively. The release profiles indicate that Hb‐loaded microcapsules conform to first‐order release kinetic in whole procedure, and 84.8%, 71.4%, and 87.3% of Hb were released during 72‐h incubation in PBS pH6.8 for microcapsules with low, medium, and high molecular weight chitosan (0.05%, w/v), respectively. The results also indicate that particle size and drug loading efficiency have a significant influence on the release profile and encapsulation efficiency. Our results reveal that the PLHis‐chitosan/alginate complex microcapsules are able to encapsulate and release Hb and are potential carriers for protein drugs. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
ISSN:0021-8995
1097-4628
DOI:10.1002/app.35371