Human Mononuclear Cell Survival and Proliferation is Modulated by Cold Atmospheric Plasma Jet

Cold plasma has become a promising application in the fields of biology and medicine. Its anti‐microbial effects and stimulating properties on eukaryotic cells make plasma an encouraging option in treatment of chronic wounds. Apart from fibroblasts or keratinocytes, immune cells have a major contrib...

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Bibliographic Details
Published in:Plasma processes and polymers 2013-08, Vol.10 (8), p.706-713
Main Authors: Bekeschus, Sander, Masur, Kai, Kolata, Julia, Wende, Kristian, Schmidt, Anke, Bundscherer, Lena, Barton, Annemarie, Kramer, Axel, Bröker, Barbara, Weltmann, Klaus-Dieter
Format: Article
Language:English
Subjects:
Argon plasma
Atmospheric pressure
Barometric pressure
Biology
cold plasma
Exact sciences and technology
Human
human immune cells
Medicine
Physics
Physics of gases, plasmas and electric discharges
Physics of plasmas and electric discharges
Plasma
Plasma applications
plasma jet
plasma medicine
proliferation
Survival
Viability
Wound healing
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Summary:Cold plasma has become a promising application in the fields of biology and medicine. Its anti‐microbial effects and stimulating properties on eukaryotic cells make plasma an encouraging option in treatment of chronic wounds. Apart from fibroblasts or keratinocytes, immune cells have a major contribution in wound healing. In this study, human peripheral blood mononuclear cells (PBMC) were tested for viability and proliferation after treatment with an atmospheric pressure argon plasma jet. In a treatment time dependent manner compromised viability of PBMC and proliferation of T cells could be shown and was assigned to induced apoptosis. Negligible cell damage was observed after short plasma exposure. Finally, plasma did not cause loss of function and treated but viable T cells retained the ability to proliferate. The translation of physical technologies into medicine and biology is one of the most potent fields of science. In plasma medicine astonishing results were archived regarding its potential use in the treatment of chronic wounds. We here investigated the argon plasma – cell interactions of an atmospheric pressure argon plasma jet to human immune cells regarding their survival and proliferation.
ISSN:1612-8850
1612-8869
DOI:10.1002/ppap.201300008