Evaluation of total oxidative status and total antioxidant capacity in patients with endemic fluorosis

• Published in: Toxicology and industrial health 2013-03, Vol.29 (2), p.175-180
• Main Authors: Varol, Ercan, Icli, Atilla, Aksoy, Fatih, Bas, Hasan Aydin, Sutcu, Recep, Ersoy, Ismail Hakki, Varol, Simge, Ozaydin, Mehmet
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants; Antioxidants - metabolism; Body mass index; Control equipment; Correlation analysis; Dental enamel; Dental fluorosis; Drinking water; Endemic Diseases; Female; Females; Fluoride Poisoning - diagnosis; Fluoride Poisoning - epidemiology; Fluoride Poisoning - metabolism; Fluorides; Fluorides - adverse effects; Fluorides - urine; Fluorosis, Dental - diagnosis; Fluorosis, Dental - epidemiology; Fluorosis, Dental - metabolism; Humans; Hydrogen peroxide; Male; Males; Middle Aged; Oxidative stress; Oxidative Stress - drug effects; Patients; Plasma; Toxicology; Turkey - epidemiology; Urine
• ISSN: 0748-2337; 1477-0393
• DOI: 10.1177/0748233711428641

The objective of the present study was to determine the plasma total oxidative status (TOS) and total antioxidant capacity (TAC) in patients with endemic fluorosis. A total of 79 (35 males and 44 females; mean age 44.0 ± 11.9 years) patients with endemic fluorosis and 55 (23 males and 32 females; mean age 48.3 ± 8.5 years) age-, sex- and body mass index-matched healthy controls were included in this study. The urine fluoride levels and plasma TOS and TAC levels were measured. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.91 ± 0.15 vs. 0.49 ± 0.13 mg/L, respectively; p < 0.001). TOS was significantly higher in fluorosis group than in control group (17.55 ± 3.82 vs. 15.06 ± 4.31 μmol H2O2 Eq/L, respectively; p = 0.001). TAC was significantly lower in fluorosis group than in control group (1.60 ± 0.36 vs. 1.82 ± 0.51 mmol Trolox Eq/L, respectively; p = 0.004). Oxidative stress index (OSI) was significantly higher in fluorosis group than in control group (11.5 ± 3.8 vs. 8.8 ± 3.7, respectively; p < 0.001). Correlation analysis in all the groups indicated that TAC was negatively correlated with urine fluoride (r = −0.25, p = 0.003), TOS was positively correlated with urine fluoride (r = 0.34, p < 0.001) and OSI was positively correlated with urine fluoride (r = 0.36, p < 0.001). The results of our study demonstrate that oxidative stress plays an important role in the pathogenesis of the endemic fluorosis.