Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T sub(1) MR images in a 1.5 T MR field

The dependence of longitudinal (r sub(1)) and transverse (r sub(2)) water proton relaxivities of ultrasmall gadolinium oxide (Gd sub(2)O sub(3)) nanoparticles on the surface coating ligand-size was investigated. Both r sub(1) and r sub(2) values decreased with increasing ligand-size. We attributed t...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2014-08, Vol.16 (37), p.19866-19873
Main Authors: Kim, Cho Rong, Baeck, Jong Su, Chang, Yongmin, Bae, Ji Eun, Chae, Kwon Seok, Lee, Gang Ho
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Gadolinium oxides
In vivo testing
In vivo tests
Magnetic resonance imaging
Nanoparticles
Surgical implants
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Summary:The dependence of longitudinal (r sub(1)) and transverse (r sub(2)) water proton relaxivities of ultrasmall gadolinium oxide (Gd sub(2)O sub(3)) nanoparticles on the surface coating ligand-size was investigated. Both r sub(1) and r sub(2) values decreased with increasing ligand-size. We attributed this to the ligand-size effect. In addition the effectiveness of d-glucuronic acid-coated ultrasmall Gd sub(2)O sub(3) nanoparticles as T sub(1) magnetic resonance imaging (MRI) contrast agents was confirmed by measuring the in vitrocytotoxicity and using in vivo T sub(1) MR images in a mouse in a 1.5 T MR field.
ISSN:1463-9076
1463-9084
DOI:10.1039/c4cp01946f