Implications of surface passivation on physicochemical and bioimaging properties of carbon dots

The prevalence of surface functionalized carbon dots (CDs) with intriguing fluorescence properties has given a new dimension to the field of bioimaging and is perceived as a promising alternative to quantum dots (QDs). In the present work, polyethylene glycol (PEG) and polyethyleneimine (PEI) passiv...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (40), p.20915-20921
Main Authors: Sachdev, Abhay, Matai, Ishita, Gopinath, P.
Format: Article
Language:English
Subjects:
Biotechnology
Cadmium
Cadmium sulfides
Carbon
Carbonization
Polyetherimides
Polyethylene glycol
Quantum dots
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Summary:The prevalence of surface functionalized carbon dots (CDs) with intriguing fluorescence properties has given a new dimension to the field of bioimaging and is perceived as a promising alternative to quantum dots (QDs). In the present work, polyethylene glycol (PEG) and polyethyleneimine (PEI) passivated CDs have been synthesized by one-step hydrothermal carbonization of chitosan. We have made a comparative analysis of the physicochemical and bioimaging properties of PEI based carbon dots (CD-PEI) and PEG based carbon dots (CD-PEG). This article further provides an insight into the role of surface functionality in controlling the bioimaging efficiencies of CDs. The concentration dependent cytotoxic effects of CD-PEI and CD-PEG were studied on normal (BHK-21) and cancer (A549) cell lines and we explored the competitive performance of CD-PEI compared to CD-PEG for bio-applications.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA02017K