Changes in diffusion path length with old age in diffuse optical tomography

Diffuse, optical near infrared imaging is increasingly being used in various neurocognitive contexts where changes in optical signals are interpreted through activation maps. Statistical population comparison of different age or clinical groups rely on the relative homogeneous distribution of measur...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2012-05, Vol.17 (5), p.056002-056002
Main Authors: Bonne´ry, Cle´ment, Leclerc, Paul-Olivier, Desjardins, Miche le, Hoge, Rick, Bherer, Louis, Pouliot, Philippe, Lesage, Fre´de´ric
Format: Article
Language:English
Subjects:
Adult
Age
Aged
aging
Aging - pathology
Aging - physiology
Anatomy
Brain - anatomy & histology
Brain - physiology
diffuse optical tomography
Diffusion
Humans
Imaging
Infrared Rays
magnetic resonance imaging
Middle Aged
Optical properties
Population (statistical)
Reproducibility of Results
Sensitivity and Specificity
Simulation
time-domain optical imaging
Tomography, Optical - methods
Young Adult
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Summary:Diffuse, optical near infrared imaging is increasingly being used in various neurocognitive contexts where changes in optical signals are interpreted through activation maps. Statistical population comparison of different age or clinical groups rely on the relative homogeneous distribution of measurements across subjects in order to infer changes in brain function. In the context of an increasing use of diffuse optical imaging with older adult populations, changes in tissue properties and anatomy with age adds additional confounds. Few studies investigated these changes with age. Duncan et al. measured the so-called diffusion path length factor (DPF) in a large population but did not explore beyond the age of 51 after which physiological and anatomical changes are expected to occur [ 39(5), 889-894 (1996)]. With increasing interest in studying the geriatric population with optical imaging, we studied changes in tissue properties in young and old subjects using both magnetic resonance imaging (MRI)-guided Monte-Carlo simulations and time-domain diffuse optical imaging. Our results, measured in the frontal cortex, show changes in DPF that are smaller than previously measured by Duncan et al. in a younger population. The origin of these changes are studied using simulations and experimental measures.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.17.5.056002