Spatial patterning of the neonatal EEG suggests a need for a high number of electrodes

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2013-03, Vol.68, p.229-235
• Main Authors: Odabaee, Maryam, Freeman, Walter J., Colditz, Paul B., Ramon, Ceon, Vanhatalo, Sampsa
• Format: Article
• Language: English
• Subjects: Arrays; Brain - physiology; Conductivity; Demand analysis; Electrodes; Electroencephalography - instrumentation; Electroencephalography - methods; Frequency spectrum; Head model; High density; High resolution EEG; Humans; Infant, Newborn; Medical research; Neurosciences; Patterning; SAT; Signal Processing, Computer-Assisted; Skull; Source localization; Spatial sampling; Spatial spectrum
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2012.11.062

There is an increasing demand for source analysis of neonatal EEG, but currently there is inadequate knowledge about i) the spatial patterning of neonatal scalp EEG and hence ii) the number of electrodes needed to capture neonatal EEG in full spatial detail. This study addresses these issues by using a very high density (2.5mm interelectrode spacing) linear electrode array to assess the spatial power spectrum, by using a high density (64 electrodes) EEG cap to assess the spatial extent of the common oscillatory bouts in the neonatal EEG and by using a neonatal size spherical head model to assess the effects of source depth and skull conductivities on the spatial frequency spectrum. The linear array recordings show that the spatial power spectrum decays rapidly until about 0.5–0.8cycles per centimeter. The dense array EEG recordings show that the amplitude of oscillatory events decays within 4–6cm to the level of global background activity, and that the higher frequencies (12–20Hz) show the most rapid spatial decline in amplitude. Simulation with spherical head model showed that realistic variation in skull conductivity and source depths can both introduce orders of magnitude difference in the spatial frequency of the scalp EEG. Calculation of spatial Nyquist frequencies from the spatial power spectra suggests that an interelectrode distance of about 6–10mm would suffice to capture the full spatial texture of the raw EEG signal at the neonatal scalp without spatial aliasing or under-sampling. The spatial decay of oscillatory events suggests that a full representation of their spatial characteristics requires an interelectrode distance of 10–20mm. The findings show that the conventional way of recording neonatal EEG with about 10 electrodes ignores most spatial EEG content, that increasing the electrode density is necessary to improve neonatal EEG source localization and information extraction, and that prospective source models will need to carefully consider the neonatally relevant ranges of tissue conductivities and source depths when source localizing cortical activity in neonates. ► The spatial patterning of scalp EEG is very dense in neonates. ► Oscillatory events in the neonatal scalp EEG are spatially confined. ► An optimal neonatal EEG recording would require significantly more electrodes.