Influence of EDTA and dentine in tissue dissolution ability of sodium hypochlorite

This study verified whether ethylenediaminetetraacetic acid (EDTA) influences the pulp tissue dissolution capability of different concentrations of NaOCl, in the presence of dentine. NaOCl and EDTA solutions were simultaneously mixed in flasks either containing a dentine disc or those not containing...

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Bibliographic Details
Published in:Australian endodontic journal 2015-04, Vol.41 (1), p.7-11
Main Authors: de Almeida, Luiza Helena Silva, Leonardo, Natália Gomes e Silva, Gomes, Ana Paula Neutzling, Souza, Erick Miranda, Pappen, Fernanda Geraldes
Format: Article
Language:English
Subjects:
Animals
Cattle
Dental Pulp - drug effects
Dentin - physiology
dentine
Dentistry
Dissolution
Dose-Response Relationship, Drug
Edetic Acid - pharmacology
EDTA
Humans
sodium hypochlorite
Sodium Hypochlorite - pharmacology
Solubility
tissue dissolution
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Summary:This study verified whether ethylenediaminetetraacetic acid (EDTA) influences the pulp tissue dissolution capability of different concentrations of NaOCl, in the presence of dentine. NaOCl and EDTA solutions were simultaneously mixed in flasks either containing a dentine disc or those not containing a dentine disc. Previously weighed bovine pulp tissues were immersed in the solutions for 5, 15 and 30 min. The weight loss was measured. The dissolution tests were performed in triplicate. Univariate analysis of variance, along with further Tukey's honestly significant difference pairwise comparisons, was used to verify the effect of EDTA, different concentrations of NaOCl, dentine and time of incubation on the tissue dissolution. Higher concentrations of NaOCl increased the tissue dissolution. EDTA reduced the capacity of NaOCl to dissolve pulp tissue, even in presence of dentine. Dentine negatively affects the capacity of NaOCl to dissolve pulp tissue. In conclusion, the presence of EDTA and dentine negatively affects the tissue dissolution ability of NaOCl.
ISSN:1329-1947
1747-4477
DOI:10.1111/aej.12044