Plasma aldosterone and its relationship with left ventricular mass in hypertensive patients with early-stage chronic kidney disease

Plasma aldosterone concentrations (PACs) are often increased in the advanced stages of chronic kidney disease (CKD); however, PAC has not been fully investigated in early CKD. Moreover, little is known about the relationship between aldosteronemia and left ventricular (LV) mass in subjects with mild...

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Bibliographic Details
Published in:Hypertension research 2015-04, Vol.38 (4), p.276-283
Main Authors: Mulè, Giuseppe, Nardi, Emilio, Guarino, Laura, Cacciatore, Valentina, Geraci, Giulio, Calcaterra, Ilenia, Oddo, Bruno, Vaccaro, Francesco, Cottone, Santina
Format: Article
Language:English
Subjects:
ACE inhibitors
Adult
Aged
Aldosterone - blood
Blood Pressure
Creatinine - blood
Female
Geometry
Humans
Hypertension
Hypertension - blood
Hypertension - complications
Hypertension - pathology
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - complications
Hypertrophy, Left Ventricular - pathology
Kidney diseases
Kidney Function Tests
Male
Middle Aged
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - pathology
Uric Acid - blood
Waist Circumference
Young Adult
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Summary:Plasma aldosterone concentrations (PACs) are often increased in the advanced stages of chronic kidney disease (CKD); however, PAC has not been fully investigated in early CKD. Moreover, little is known about the relationship between aldosteronemia and left ventricular (LV) mass in subjects with mild-to-moderate CKD. The study objectives were to analyze PAC, LV mass (LVM), LV geometry and their relationships, in a group of hypertensive patients with stage I-III CKD. One hundred ninety-five hypertensive patients with stage I-III CKD were enrolled and compared with a control group of 82 hypertensive patients without renal dysfunction. LVM was higher in subjects with CKD than in the control group and increased progressively with advancing stages of CKD (P=0.004). A similar trend was observed for PAC (P
ISSN:0916-9636
1348-4214
DOI:10.1038/hr.2014.171