Comparison of Seven-Day and Repeated 24-Hour Recall of Symptoms in the First 100 Days After Hematopoietic Cell Transplantation

• Published in: Journal of pain and symptom management 2015-03, Vol.49 (3), p.513-520
• Main Authors: Wood, William A., MD, MPH, Deal, Allison M., MS, Bennett, Antonia V., PhD, Mitchell, Sandra A., CRNP, PhD, AOCN, Abernethy, Amy P., MD, PhD, Basch, Ethan, MD, Bailey, Charlotte, MA, Reeve, Bryce B., PhD
• Format: Article
• Language: English
• Subjects: Anesthesia & Perioperative Care; Cohort Studies; Feasibility Studies; Hematopoietic stem cell transplantation; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Medical Records; Middle Aged; Pain Medicine; patient-reported outcomes; Pilot Projects; PRO-CTCAE; Self Report; Surveys and Questionnaires; symptom burden; Time Factors
• ISSN: 0885-3924; 1873-6513
• DOI: 10.1016/j.jpainsymman.2014.06.011

Abstract Context Patient-reported outcomes (PROs) provide a way to understand the effects of hematopoietic cell transplantation (HCT)-related stress on patients' lives. We previously reported that weekly collection of PROs is feasible. Objectives Here, we report on the feasibility of daily patient-reported symptom collection and examine the relationship between daily vs. weekly symptom reporting over time. Methods We analyzed data from 32 autologous and allogeneic HCT patients obtained until Day (D) +100. We used questions from the PRO version of the Common Terminology Criteria for Adverse Events to capture symptoms. Results We found that overall rates of daily survey completion were moderate to high (range 67%–86%). The effect size of the difference between the maximum daily severity score and the weekly severity score ranged from 0.15 to 0.35, and the concordance correlation coefficient ranged from 0.513 to 0.834. Concordance of daily and weekly surveys was higher for maximum daily severity rating and mean daily severity rating than for minimum daily severity rating or most recent daily severity rating. Conclusion We conclude that a seven-day recall period for symptom severity provides acceptable accuracy and precision in the first 100 days after HCT. Further studies to explore the utility of daily symptom reporting within specific clinical contexts may be warranted.