Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Rier, S. E., Martin, D. C., Bowman, R. E., Dmowski, W. P., and Becker, J. L. (1993). Fundam. Appl. Toxicol. 21, 433-441. The incidence of the reproductive disease endometriosis was det...

Full description

Saved in:
Bibliographic Details
Published in:Fundamental and applied toxicology 1993-11, Vol.21 (4), p.433-441
Main Authors: Rier, Sherry E., Martin, Dan C., Bowman, Robert E., Dmowski, W.Paul, Becker, Jeanne L.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
COMPOSE ORGANOCHLORE
COMPUESTO ORGANICO DEL CLORO
Endometriosis - chemically induced
Endometriosis - epidemiology
Endometriosis - veterinary
Female
HIDROCARBUROS HALOGENADOS
HYDROCARBURE HALOGENE
Macaca mulatta
Medical sciences
Monkey Diseases - epidemiology
MONO
Polychlorinated Dibenzodioxins - administration & dosage
Polychlorinated Dibenzodioxins - toxicity
SINGE
TOXICIDAD
TOXICITE
Toxicology
TRASTORNOS DE LA REPRODUCCION
TROUBLE DE LA REPRODUCTION
Various organic compounds
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Rier, S. E., Martin, D. C., Bowman, R. E., Dmowski, W. P., and Becker, J. L. (1993). Fundam. Appl. Toxicol. 21, 433-441. The incidence of the reproductive disease endometriosis was determined in a colony of rhesus monkeys chronically exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) for a period of 4 years. Ten years after termination of dioxin treatment, the presence of endometriosis was documented by surgical laparoscopy and the severity of disease was assessed. The incidence of endometriosis was directly correlated with dioxin exposure and the severity of disease was dependent upon the dose administered (p < 0.001). Three of 7 animals exposed to 5 ppt dioxin (43%) and 5 of 7 animals exposed to 25 ppt dioxin (71%) had moderate to severe endometriosis. In contrast, the frequency of disease in the control group was 33%, similar to an overall prevalence of 30% in 304 rhesus monkeys housed at The Harlow Primate Center with no dioxin exposure. This 15-year study indicates that latent female reproductive abnormalities may be associated with dioxin exposure in the rhesus. Therefore, the effects of this toxin may be more diverse than previously recognized.
ISSN:0272-0590
1095-6832
DOI:10.1006/faat.1993.1119