Anti-diarrheal medication use in the treatment of Ebola virus-induced diarrhea

The hypothesis that Ebola virus is an enteroadherent pathogen is strengthened by recent autopsy reports confirming the presence of viral antigens within mononuclear cells in the lamina propria of gastric, small intestinal and colonic mucosa [4]. For the current West African outbreak there are no pub...

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Bibliographic Details
Published in:Travel medicine and infectious disease 2015-03, Vol.13 (2), p.205-206
Main Authors: Kendall, Ronald E, Gosser, Rena A, Schulz, Lucas T, Trapskin, Philip J, Caponi, Bartho, Safdar, Nasia
Format: Article
Language:English
Subjects:
Anti-diarrheals
Antidiarrheals - therapeutic use
Dehydration
Diarrhea
Diarrhea - drug therapy
Diarrhea - virology
Ebola
Ebola virus
Ebolavirus
Fever
Hemorrhagic Fever, Ebola
Humans
Infectious Disease
Patients
Supportive care
Travel medicine
Viral gastroenteritis
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Summary:The hypothesis that Ebola virus is an enteroadherent pathogen is strengthened by recent autopsy reports confirming the presence of viral antigens within mononuclear cells in the lamina propria of gastric, small intestinal and colonic mucosa [4]. For the current West African outbreak there are no published standard treatment approaches to EVD-induced diarrhea. [...]some providers are hesitant to use anti-diarrheal medications while others use these medications to limit severe dehydration and shock in hypovolemic patients [3].
ISSN:1477-8939
1873-0442
DOI:10.1016/j.tmaid.2015.01.003