Hierarchical clustering identifies a subgroup of colonic adenocarcinomas expressing crypt-like differentiation markers, associated with MSS status and better prognosis

The aim of this study was to identify in the group of colonic adenocarcinomas, not otherwise specified (NOS), subgroups of oncogenetic and prognostic significance based on the expression of immunohistochemical markers of epithelial cell differentiation of the gastrointestinal tract. Hierarchical clu...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2015-04, Vol.466 (4), p.383-391
Main Authors: Droy-Dupré, Laure, Bossard, Céline, Volteau, Christelle, Bezieau, Stéphane, Laboisse, Christian L., Mosnier, Jean-François
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
CDX2 Transcription Factor
Cell differentiation
Cluster Analysis
Colonic Neoplasms - mortality
Colonic Neoplasms - pathology
Female
Gastrointestinal tract
Homeodomain Proteins - analysis
Homeodomain Proteins - biosynthesis
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Keratin-20 - analysis
Keratin-20 - biosynthesis
Keratin-7 - analysis
Keratin-7 - biosynthesis
Male
Medicine
Medicine & Public Health
Microsatellite Instability
Middle Aged
Mucin 5AC - analysis
Mucin 5AC - biosynthesis
Mucin-2 - analysis
Mucin-2 - biosynthesis
Original Article
Pathology
Prognosis
Tissue Array Analysis
Young Adult
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Summary:The aim of this study was to identify in the group of colonic adenocarcinomas, not otherwise specified (NOS), subgroups of oncogenetic and prognostic significance based on the expression of immunohistochemical markers of epithelial cell differentiation of the gastrointestinal tract. Hierarchical clustering analysis of 122 adenocarcinomas (NOS) identified four clusters based on how closely their profile of immunohistochemical expression of differentiation markers was related: (i) a major cluster of 83 adenocarcinomas (68 %) called crypt-like carcinoma (CLA) with a immunohistochemically expressing colonic crypt differentiation markers (cytokeratin 20+, CDX2+, MUC2+ or MUC2−) and (ii) three minor clusters, characterized by the loss of colonic crypt differentiation markers and/or the acquisition of expression of markers of metaplastic foveolar gastric differentiation (MUC5AC+) and/or aberrant cytokeratin 7 expression. CLAs were invariably MSS ( χ 2 test: p  
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-015-1724-9