The role of filaggrin in the skin barrier and disease development

Filaggrin is a structural protein that is fundamental in the development and maintenance of the skin barrier. The function of filaggrin and its involvement in various cutaneous and extracutaneous disorders has been the subject of considerable research in recent years. Mutations in FLG, the gene that...

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Bibliographic Details
Published in:Actas dermo-sifiliográficas (English ed.) 2015-03, Vol.106 (2), p.86-95
Main Authors: Armengot-Carbo, M, Hernández-Martín, Á, Torrelo, A
Format: Article
Language:eng ; spa
Subjects:
Humans
Intermediate Filament Proteins - genetics
Intermediate Filament Proteins - physiology
Mutation
Skin Diseases - etiology
Skin Physiological Phenomena
Online Access:Get full text
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Summary:Filaggrin is a structural protein that is fundamental in the development and maintenance of the skin barrier. The function of filaggrin and its involvement in various cutaneous and extracutaneous disorders has been the subject of considerable research in recent years. Mutations in FLG, the gene that encodes filaggrin, have been shown to cause ichthyosis vulgaris, increase the risk of atopic dermatitis and other atopic diseases, and exacerbate certain conditions. The present article reviews the current knowledge on the role of filaggrin in the skin barrier, FLG mutations, and the consequences of filaggrin deficiency.
ISSN:1578-2190
DOI:10.1016/j.ad.2013.10.019