Hemoglobin C in a patient with sickle cell anemia: Transfusion-acquired SC disease

•We report a sickle cell anemia patient who had low amounts of hemoglobin C following routine red cell exchange transfusion•Analysis of anonymized donor segments from the transfused units showed hemoglobin C trait in one of the donors•Laboratorians and physicians should be aware of potential pre-ana...

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Bibliographic Details
Published in:Clinical biochemistry 2015-04, Vol.48 (6), p.463-464
Main Authors: Estey, Mathew P., Capote, Karina Rodriguez, Barakauskas, Vilte E., Clarke, Gwen, Higgins, Trefor
Format: Article
Language:English
Subjects:
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - etiology
Hemoglobin C
Hemoglobin C - metabolism
Hemoglobinopathy
Humans
Red cell exchange transfusion
SC disease
Sickle cell anemia
Transfusion Reaction
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Summary:•We report a sickle cell anemia patient who had low amounts of hemoglobin C following routine red cell exchange transfusion•Analysis of anonymized donor segments from the transfused units showed hemoglobin C trait in one of the donors•Laboratorians and physicians should be aware of potential pre-analytical errors in hemoglobin fractionation post transfusion
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2015.01.013