MARTINOMYCIN, A NEW POLYETHER ANTIBIOTIC PRODUCED BY Streptomyces salvialis: I. TAXONOMY, FERMENTATION AND BIOLOGICAL ACTIVITY

Actinomycete culture LL-D37187 has been found to produce the new polyether antibiotic martinomycin1). Taxonomic studies, including morphological, physiological, and cell wall chemistry analyses, revealed that culture LL-D37187 is a novel streptomycete species, and the proposed name is Streptomyces s...

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Bibliographic Details
Published in:Journal of antibiotics 1994/12/25, Vol.47(12), pp.1434-1441
Main Authors: BERNAN, VALERIE S., MONTEREGRO, DEBORAH A., GOODMAN, JOSEPH J., ALLURI, MAHENDER R., CARTER, GUY T., ABBANT, DARREN R., PEARCE, CEDRIC J., MAIESE, WILLIAM M., GREENSTEIN, MICHAEL
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Artemia - drug effects
Biological and medical sciences
Ethers - pharmacology
Fermentation
Gram-Positive Bacteria - drug effects
Insecticides - pharmacology
Medical sciences
Microscopy, Electron, Scanning
Molecular Structure
Pharmacology. Drug treatments
Spodoptera
Streptomyces - classification
Streptomyces - metabolism
Streptomyces - ultrastructure
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Summary:Actinomycete culture LL-D37187 has been found to produce the new polyether antibiotic martinomycin1). Taxonomic studies, including morphological, physiological, and cell wall chemistry analyses, revealed that culture LL-D37187 is a novel streptomycete species, and the proposed name is Streptomyces salvialis. Martinomycin exhibits activity against the Southern Army Worm (Spodoptera eridania) and Gram-positive bacteria.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.47.1434