Engineering therapeutic proteins for cell entry: the natural approach

Highlights • Toxins and viruses provide natural templates for the design of intracellular biologics. • Endosomal entrapment is a major issue for cytoplasmic delivery. • Antibodies are effective in redirecting toxin catalytic domains for therapy. • Protein engineering can address intracellular stabil...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2015-03, Vol.33 (3), p.163-171
Main Authors: Guillard, Sandrine, Minter, Ralph R, Jackson, Ronald H
Format: Article
Language:English
Subjects:
Anthrax
Antigens
Biological Therapy - methods
Cytoplasm
Diphtheria
Epidermal growth factor
Growth hormones
Humans
Influenza
Internal Medicine
intracellular
Ligands
Membranes
protein
Protein Engineering - methods
Protein synthesis
Protein Transport
Proteins
Proteins - pharmacokinetics
Proteins - therapeutic use
Recombinant Proteins - pharmacokinetics
Recombinant Proteins - therapeutic use
toxin
Toxins
virus
Viruses
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Summary:Highlights • Toxins and viruses provide natural templates for the design of intracellular biologics. • Endosomal entrapment is a major issue for cytoplasmic delivery. • Antibodies are effective in redirecting toxin catalytic domains for therapy. • Protein engineering can address intracellular stability and potency.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2014.12.004