Efficient hydrolysis of β-substituted methyl esters susceptible to elimination by pig liver esterase

Methyl esters substituted at beta position with good leaving groups (nucleofugals) are smoothly hydrolysed by Pig Liver Esterase (PLE) in moderate to high yields.

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Bibliographic Details
Published in:Biotechnology letters 1993-11, Vol.15 (11), p.1147-1150
Main Authors: Mahato, T K, Babu, S, Basak, A
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Online Access:Get full text
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Description
Summary:Methyl esters substituted at beta position with good leaving groups (nucleofugals) are smoothly hydrolysed by Pig Liver Esterase (PLE) in moderate to high yields.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF00131206