Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission

In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1–2 weeks full‐body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and stren...

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Bibliographic Details
Published in:Scandinavian journal of medicine & science in sports 2015-04, Vol.25 (2), p.175-183
Main Authors: Jespersen, J. G., Mikkelsen, U. R., Nedergaard, A., Thorlund, J. B., Schjerling, P., Suetta, C., Christensen, P. A., Aagaard, P.
Format: Article
Language:English
Subjects:
Adult
atrogenes
Blotting, Western
Denmark
Humans
Immobilization - physiology
Male
Military Personnel
mTOR
muscle atrophy
Muscle Proteins - metabolism
Muscle Strength - physiology
Muscular Atrophy - metabolism
Musculoskeletal system
Nutrition
Occupational Diseases - metabolism
Prone Position - physiology
Proteins
Quadriceps Muscle - metabolism
Reverse Transcriptase Polymerase Chain Reaction
Ribonucleic acid
RNA
signaling
soldiers
Special forces
Unloading
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Summary:In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1–2 weeks full‐body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and strength are necessary in combat or evacuation situations, which prompt for improved understanding of muscle mass modulation during SSR missions. To explore the molecular regulation of myofiber size during a simulated SSR operation, nine male Special Forces soldiers were biopsied in m. vastus lateralis pre and post 8 days immobilizing restricted prone position. After immobilization, total mammalian target of rapamycin protein was reduced by 42% (P 
ISSN:0905-7188
1600-0838
DOI:10.1111/sms.12170