Epidemiological history and genomic characterization of non-D1 HBV strains identified in Iran

Highlights • Rare HBV subgenotypes D2 and D3 detected in Iran have non-European common ancestors. • Iranian D2 and D3 strains diverged from west and south Asian HBV strains, respectively. • D2 was introduced at least two times in the 1950s and D3 one time (∼1967) to Iran. • We report HBV D3 strains...

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Bibliographic Details
Published in:Journal of clinical virology 2015-02, Vol.63, p.38-41
Main Authors: Pineda-Peña, Andrea-Clemencia, Faria, Nuno Rodrigues, Mina, Thomas, Amini-Bavil-Olyaee, Samad, Alavian, Seyed Moayed, Lemey, Philippe, Maes, Piet, Ranst, Marc Van, Pourkarim, Mahmoud Reza
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Ancestor
Carrier State - epidemiology
Carrier State - virology
Cluster Analysis
DNA, Viral - chemistry
DNA, Viral - genetics
Evolution
Evolution, Molecular
Female
Genetic Variation
Genome, Viral
Genotype
Hepatitis B - epidemiology
Hepatitis B - virology
Hepatitis B virus
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Humans
Infectious Disease
Iran
Iran - epidemiology
Male
Middle Aged
Molecular Epidemiology
Molecular Sequence Data
Mutation
Phylogeny
Sequence Analysis, DNA
Sequence Homology
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Summary:Highlights • Rare HBV subgenotypes D2 and D3 detected in Iran have non-European common ancestors. • Iranian D2 and D3 strains diverged from west and south Asian HBV strains, respectively. • D2 was introduced at least two times in the 1950s and D3 one time (∼1967) to Iran. • We report HBV D3 strains that carry adw2 subtype-like HBV non-D genotypes. • Medically important genome mutations of Iranian D2 and D3 strains differ from D1.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2014.12.010