Dopamine-Angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease

ABSTRACT Renin‐angiotensin systems are known to act in many tissues, for example, the blood vessel wall or kidney, where a close interaction between angiotensin and dopamine has been demonstrated. Regulatory interactions between the dopaminergic and renin‐angiotensin systems have recently been descr...

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Published in:Movement disorders 2013-09, Vol.28 (10), p.1337-1342
Main Authors: Labandeira-Garcia, Jose L., Rodriguez-Pallares, Jannette, Dominguez-Meijide, Antonio, Valenzuela, Rita, Villar-Cheda, Begoña, Rodríguez-Perez, Ana I.
Format: Article
Language:English
Subjects:
aging
angiotensin
Angiotensins - physiology
Basal Ganglia - physiology
Brain - physiopathology
Data Interpretation, Statistical
degenerative disease
dopamine
Dopamine - physiology
Humans
Movement disorders
Neostriatum - physiopathology
neurodegeneration
neuroinflammation
oxidative stress
Paracrine Communication - physiology
Parkinson Disease - physiopathology
Parkinson's
renin-angiotensin system
Renin-Angiotensin System - physiology
Substantia Nigra - physiopathology
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Summary:ABSTRACT Renin‐angiotensin systems are known to act in many tissues, for example, the blood vessel wall or kidney, where a close interaction between angiotensin and dopamine has been demonstrated. Regulatory interactions between the dopaminergic and renin‐angiotensin systems have recently been described in the substantia nigra and striatum. In animal models, dopamine depletion induces compensatory overactivation of the local renin‐angiotensin system, which primes microglial responses and neuron vulnerability by activating NADPH‐oxidase. Hyperactivation of the local renin‐angiotensin system exacerbates the inflammatory microglial response, oxidative stress, and dopaminergic degeneration, all of which are inhibited by angiotensin receptor blockers and inhibitors of angiotensin‐converting enzymes. In this review we provide evidence suggesting that the renin‐angiotensin system may play an important role in dopamine's mediated neuroinflammation and oxidative stress changes in Parkinson's disease. We suggest that manipulating brain angiotensin may constitute an effective neuroprotective strategy for Parkinson's disease. © 2013 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.25614