Assessment of hemodialysis impact by Polysulfone membrane on brain plasticity using BOLD-fMRI

Highlights • Group analysis results confirm individual analysis for both intensity and volume of BOLD indicating the activated brain area. • A clear and significant increase of the oxidative stress after hemodialysis was shown. • Strong relationship between oxidative stress and BOLD-fMRI results was...

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Bibliographic Details
Published in:Neuroscience 2015-03, Vol.288, p.94-104
Main Authors: Belaïch, R, Boujraf, S, Housni, A, Maaroufi, M, Batta, F, Magoul, R, Sqalli, T, Errasfa, M, Tizniti, S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antioxidants - metabolism
BOLD-fMRI
brain function
Brain Mapping
Cerebrovascular Circulation - physiology
Fingers - physiology
functional control
hemodialysis
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging - methods
Male
Malondialdehyde - metabolism
Middle Aged
Motor Activity - physiology
Motor Cortex - physiopathology
Neurology
Neuronal Plasticity - physiology
oxidative stress
Oxidative Stress - physiology
Oxygen - blood
plasticity
Polymers
Renal Dialysis - methods
Sulfones
Young Adult
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Summary:Highlights • Group analysis results confirm individual analysis for both intensity and volume of BOLD indicating the activated brain area. • A clear and significant increase of the oxidative stress after hemodialysis was shown. • Strong relationship between oxidative stress and BOLD-fMRI results was revealed. • BOLD-fMRI shows remarkable sensitivity to brain plasticity and reorganization of the functional control after hemodialysis. • Results confirm the superiority of the BOLD-fMRI quantities to biological method for assessing the OS in the motor cortex.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.11.064