Feasibility of Adenovirus-Mediated hNIS Gene Transfer and super(131)I Radioiodine Therapy as a Definitive Treatment for Localized Prostate Cancer

We have developed a replication-competent adenovirus (Ad5 yCD/mutTK[sub SR39]rep-hNIS) armed with two suicide genes and the human sodium iodide symporter (hNIS) gene. In this context, hNIS can be used as a reporter gene in conjunction with nuclear imaging and as a potentially therapeutic gene when c...

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Bibliographic Details
Published in:Molecular therapy 2011-07, Vol.19 (7), p.1353-1359
Main Authors: Barton, Kenneth N, Stricker, Hans, Elshaikh, Mohamed A, Pegg, Jan, Cheng, Jingfang, Zhang, Yingshu, Karvelis, Kastytis C, Lu, Mei, Movsas, Benjamin, Freytag, Svend O
Format: Article
Language:English
Subjects:
Adenovirus
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Summary:We have developed a replication-competent adenovirus (Ad5 yCD/mutTK[sub SR39]rep-hNIS) armed with two suicide genes and the human sodium iodide symporter (hNIS) gene. In this context, hNIS can be used as a reporter gene in conjunction with nuclear imaging and as a potentially therapeutic gene when combined with radioiodine therapy. Here, we quantified the volume and magnitude of hNIS gene expression in the human prostate following injection of a high Ad5-yCD/mutTK[sub SR39]rep-hNIS dose using a standardized injection algorithm, and estimated the radiation dose that would be delivered to the prostate had men been administered 131I with curative intent. We discuss the obstacles that must be overcome before adenovirus-mediated hNIS gene transfer and 131I radioiodine therapy can be used as a definitive treatment for localized prostate cancer.
ISSN:1525-0016
1525-0024
DOI:10.1038/mt.2011.89