Successful Treatment of Antimony-Resistant Visceral Leishmaniasis with Liposomal Amphotericin B in Patients Infected with Human Immunodeficiency Virus

We describe two cases of visceral leishmaniasis in patients infected with human immunodeficiency virus (HIV); both cases were resistant to antimony compounds but were cured with liposomal amphotericin B, with no significant toxicity. A review of the previous reported cases of antimony-resistant visc...

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Bibliographic Details
Published in:Clinical infectious diseases 1993-10, Vol.17 (4), p.625-627
Main Authors: Torre-Cisneros, Julian, Villanueva, Jose Luis, Kindelan, Jose Maria, Jurado, Rafael, Sanchez-Guijo, Pedro
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - drug therapy
Amphotericin B - administration & dosage
Amphotericin B - therapeutic use
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimony
Antiparasitic agents
Antiprotozoal Agents - pharmacology
Antiprotozoal Agents - therapeutic use
Biological and medical sciences
Bone marrow
Clinical Infectious Disease Articles
Dosage
Drug Carriers
Drug Resistance
Fever
Follow-Up Studies
HIV
HIV-1
human immunodeficiency virus
Humans
Immunocompromised hosts
Leishmania - drug effects
Leishmania - growth & development
Leishmaniasis
Leishmaniasis, Visceral - diagnosis
Leishmaniasis, Visceral - drug therapy
Liposomes
Macrophages
Male
Medical sciences
Meglumine - pharmacology
Meglumine - therapeutic use
Meglumine Antimoniate
Organometallic Compounds - pharmacology
Organometallic Compounds - therapeutic use
Pharmacology. Drug treatments
Tropical medicine
Visceral leishmaniasis
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Description
Summary:We describe two cases of visceral leishmaniasis in patients infected with human immunodeficiency virus (HIV); both cases were resistant to antimony compounds but were cured with liposomal amphotericin B, with no significant toxicity. A review of the previous reported cases of antimony-resistant visceral leishmaniasis in HIV-infected patients confirmed the effectiveness of treatment with liposomal amphotericin B, which directly targets infected macrophages and reaches high levels in plasma and tissue.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/17.4.625