Trichoharzianol, a New Antifungal from Trichoderma harzianum F031

A new decalin derivative, trichoharzianol (1), together with three known compounds, eujavanicol A (2), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (3), and 4,6-dihydroxy-5-methylphthalide (4), were isolated from Trichoderma harzianum F031. For the first time, compounds 2–4 were reported fro...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2015-04, Vol.63 (14), p.3704-3708
Main Authors: Jeerapong, Chotika, Phupong, Worrapong, Bangrak, Phuwadol, Intana, Warin, Tuchinda, Patoomratana
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - metabolism
Antifungal Agents - pharmacology
Colletotrichum - drug effects
Microbial Sensitivity Tests
Naphthalenes - chemistry
Naphthalenes - metabolism
Naphthalenes - pharmacology
Trichoderma - chemistry
Trichoderma - metabolism
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Summary:A new decalin derivative, trichoharzianol (1), together with three known compounds, eujavanicol A (2), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (3), and 4,6-dihydroxy-5-methylphthalide (4), were isolated from Trichoderma harzianum F031. For the first time, compounds 2–4 were reported from the Trichoderma species. Their structures were characterized by spectroscopic methods. Trichoharzianol (1) showed the highest antifungal activity against Colletotrichum gloeosporioides, with a minimum inhibitory concentration (MIC) of 128 μg/mL.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.5b01258