Life after MOMP

In this and a recent issue of Molecular Cell, Liu et al. (2015) and Ichim et al. (2015) report that low levels of caspase activity triggered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that drives tumorigenesis, providing a novel and unexpected link be...

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Bibliographic Details
Published in:Molecular cell 2015-04, Vol.58 (2), p.199-201
Main Authors: Gama, Vivian, Deshmukh, Mohanish
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
DNA Damage
Genomic Instability
Humans
Mitochondrial Membranes - physiology
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Summary:In this and a recent issue of Molecular Cell, Liu et al. (2015) and Ichim et al. (2015) report that low levels of caspase activity triggered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that drives tumorigenesis, providing a novel and unexpected link between these effectors of apoptosis and cancer initiation. In this and a recent issue of Molecular Cell, Liu et al. and Ichim et al. report that low levels of caspase activity triggered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that drives tumorigenesis, providing a novel and unexpected link between these effectors of apoptosis and cancer initiation.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2015.03.035