Homocysteine, a biomarker of osteosarcoma

The present study was planned to analyze the status of serum homocysteine (hcy), folate, and Vitamin B 12 in patients with osteosarcoma. The present study was conducted on 60 orthopedics patients who were divided into two groups, group I with 30 patients of osteosarcoma and group II with 30 patients...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2015-01, Vol.11 (1), p.51-53
Main Authors: Kharb, Simmi, Kumar, S, Kundu, Z S
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Bone Neoplasms - blood
Case-Control Studies
Diagnosis
DNA methylation
Enzymes
Female
Folic Acid - blood
Health aspects
Homocysteine
Homocysteine - blood
Humans
Identification and classification
Immunoassay
Male
Metabolism
Osteosarcoma
Osteosarcoma - blood
Studies
Vitamin B
Vitamin B 12 - blood
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Summary:The present study was planned to analyze the status of serum homocysteine (hcy), folate, and Vitamin B 12 in patients with osteosarcoma. The present study was conducted on 60 orthopedics patients who were divided into two groups, group I with 30 patients of osteosarcoma and group II with 30 patients with musculoskeletal pain. The present study indicated that serum folate and hcy levels were increased in osteosarcoma patients and decreased Vitamin B 12 in osteosarcoma patients when compared to controls. Lowered serum Vitamin B 12 levels are possibly due to increased metabolic demand of the tumor. Raised hcy levels could be due to the contribution from rapidly proliferating cells. The present study suggests that these parameters can serve as useful markers for diagnosis and follow-up of disease.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.147697