Ni-Catalyzed Highly Chemo‑, Regio‑, and Enantioselective Decarboxylative Aldol Reaction of β,γ-Unsaturated α‑Ketoesters with β‑Ketoacids

A novel Ni-catalyzed decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids is reported. The reaction proceeds smoothly with high chemo-, regio-, and enantioselectivity. This protocol provides a convenient approach to access enantioenriched chiral tertiary alcohols.

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Bibliographic Details
Published in:Journal of organic chemistry 2015-04, Vol.80 (8), p.3766-3776
Main Authors: Wei, Ai-Jia, Nie, Jing, Zheng, Yan, Ma, Jun-An
Format: Article
Language:English
Subjects:
Catalysis
Coordination Complexes - chemistry
Keto Acids - chemistry
Nickel - chemistry
Stereoisomerism
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Description
Summary:A novel Ni-catalyzed decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids is reported. The reaction proceeds smoothly with high chemo-, regio-, and enantioselectivity. This protocol provides a convenient approach to access enantioenriched chiral tertiary alcohols.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo502741z