Accuracy of OCT, grayscale IVUS, and their combination for the diagnosis of coronary TCFA: an ex vivo validation study

This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA). The extent to which the imaging characteristics of OCT and IVUS correlate with histologically defined TCFA i...

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Bibliographic Details
Published in:JACC. Cardiovascular imaging 2015-04, Vol.8 (4), p.451-460
Main Authors: Fujii, Kenichi, Hao, Hiroyuki, Shibuya, Masahiko, Imanaka, Takahiro, Fukunaga, Masashi, Miki, Kojiro, Tamaru, Hiroto, Sawada, Hisashi, Naito, Yoshiro, Ohyanagi, Mitsumasa, Hirota, Seiichi, Masuyama, Tohru
Format: Article
Language:English
Subjects:
Autopsy
Cadaver
Coronary Artery Disease - diagnosis
Coronary Artery Disease - diagnostic imaging
Humans
In Vitro Techniques
Plaque, Atherosclerotic - diagnosis
Plaque, Atherosclerotic - diagnostic imaging
Sensitivity and Specificity
Tomography, Optical Coherence - methods
Ultrasonography, Interventional - methods
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Summary:This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA). The extent to which the imaging characteristics of OCT and IVUS correlate with histologically defined TCFA is unknown. IVUS and OCT examinations identified focal plaques in 165 coronary arteries from 60 autopsy hearts. A total of 685 pairs of images of OCT and IVUS were compared with histology. By OCT, a TCFA was defined as a signal-poor region with diffuse borders and cap thickness 
ISSN:1876-7591
DOI:10.1016/j.jcmg.2014.10.015