Iridium-Catalyzed Single-Step N‑Substituted Lactam Synthesis from Lactones and Amines

Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformationsaminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamideafforded the corresponding N-substituted lactams.

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Bibliographic Details
Published in:Journal of organic chemistry 2015-04, Vol.80 (8), p.4152-4156
Main Authors: Kim, Kicheol, Hong, Soon Hyeok
Format: Article
Language:English
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Summary:Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformationsaminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamideafforded the corresponding N-substituted lactams.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b00101