Maternal toxicity of methacrylonitrile in sprague-dawley rats

Methacrylonitrile (MeAN) is used in the preparation of plastics, elastomers, homo- and copolymers and coatings. Thousands of individuals are exposed to various nitriles including MeAN, during their manufacture, processing or disposal. A review of the scientific literature on MeAN reveals a lack of i...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1992-05, Vol.48 (5), p.696-700
Main Authors: FAROOQUI, M. Y. H, VILLARREAL, M. I
Format: Article
Language:English
Subjects:
Abortion, Veterinary - chemically induced
Animals
Biological and medical sciences
Body Weight - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
Edema - chemically induced
Embryonic and Fetal Development - drug effects
Fallopian Tubes - drug effects
Female
Lethal Dose 50
Litter Size - drug effects
Male
Medical sciences
Methacrylates - toxicity
Nitriles - toxicity
Pregnancy
Pregnancy, Animal - drug effects
Rats
Rats, Inbred Strains
Toxicology
Various organic compounds
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Summary:Methacrylonitrile (MeAN) is used in the preparation of plastics, elastomers, homo- and copolymers and coatings. Thousands of individuals are exposed to various nitriles including MeAN, during their manufacture, processing or disposal. A review of the scientific literature on MeAN reveals a lack of information concerning its reproductive toxicity. The purpose of this study was to assess the potential reproductive toxicity of MeAN in rats given the compound by gavage. The oral administration was chosen because trace amounts of untreated MeAN monomer may migrate into food and beverages that are packaged in containers made of MeAN copolymers.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF00195989