The effect of estrogen synthesis inhibition on hippocampal memory

Highlights • Estradiol depletion specifically impaired hippocampus-dependent memory. • Estradiol depletion tended to decrease memory-related hippocampal activity. • Estradiol depletion increased memory-related activity in prefrontal areas. • The increased prefrontal activity reflects most likely a c...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2015-06, Vol.56, p.213-225
Main Authors: Bayer, Janine, Rune, Gabriele, Schultz, Heidrun, Tobia, Michael J, Mebes, Imke, Katzler, Olaf, Sommer, Tobias
Format: Article
Language:English
Subjects:
Aged
Aromatase inhibitors
Dual process model
Endocrinology & Metabolism
Estradiol - biosynthesis
Estrogen
Female
Gyrus Cinguli - drug effects
Hippocampus
Hippocampus - drug effects
Humans
Long-Term Potentiation - drug effects
Longitudinal Studies
Magnetic Resonance Imaging
Memory
Memory - drug effects
Memory, Short-Term - drug effects
Middle Aged
Nitriles - pharmacology
Postmenopause
Prefrontal Cortex - drug effects
Psychiatry
Psychomotor Performance - drug effects
Steroid Synthesis Inhibitors - pharmacology
Surveys and Questionnaires
Triazoles - pharmacology
Verbal Learning - drug effects
Word Association Tests
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Summary:Highlights • Estradiol depletion specifically impaired hippocampus-dependent memory. • Estradiol depletion tended to decrease memory-related hippocampal activity. • Estradiol depletion increased memory-related activity in prefrontal areas. • The increased prefrontal activity reflects most likely a compensatory mechanism.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.03.011