Change in tropism upon immune escape by human immunodeficiency virus

The V3 loop of human immunodeficiency virus type 1 is both a determinant of viral cell tropism and a target for neutralizing antibodies. This relationship was investigated. Selection of a dual tropic (T cells and macrophages) virus to replicate in CD4+ brain cells results in loss of macrophage tropi...

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Bibliographic Details
Published in:Journal of Virology 1995-05, Vol.69 (5), p.3167-3170
Main Authors: McKnight, A. (Institute of Cancer Research, London, UK.), Weiss, R.A, Shotton, C, Takeuchi, Y, Hoshino, H, Clapham, P.R
Format: Article
Language:English
Subjects:
AIDS/HIV
Amino Acid Sequence
Antibodies, Monoclonal
Antigenic Variation - genetics
ARN MENSAJERO
ARN MESSAGER
Brain - cytology
Brain - immunology
Brain - virology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
Cells, Cultured
Cloning, Molecular
CORONAVIRIDAE
EXPRESION GENICA
EXPRESSION DES GENES
GENE
GENES
HIV Antibodies
HIV Antigens - genetics
HIV Envelope Protein gp120 - genetics
HIV Envelope Protein gp120 - immunology
HIV Seropositivity - immunology
HIV Seropositivity - virology
HIV-1 - immunology
HIV-1 - pathogenicity
HIV-1 - physiology
human immunodeficiency virus 1
Humans
Macrophages - immunology
Macrophages - virology
Molecular Sequence Data
Neutralization Tests
Organ Specificity
Peptide Fragments - genetics
Peptide Fragments - immunology
SECUENCIA NUCLEICA
SEQUENCE NUCLEIQUE
VARIACION GENETICA
VARIATION GENETIQUE
Virus Replication - immunology
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Summary:The V3 loop of human immunodeficiency virus type 1 is both a determinant of viral cell tropism and a target for neutralizing antibodies. This relationship was investigated. Selection of a dual tropic (T cells and macrophages) virus to replicate in CD4+ brain cells results in loss of macrophage tropism and of neutralization by an anti-V3 loop monoclonal antibody. Moreover, selection of the brain-selected variant to escape from V3 loop-specific neutralizing monoclonal antibodies results in the reduction or loss of brain cell tropism and the reacquisition of macrophage tropism. These data may indicate that the antigenic diversification of human immunodeficiency virus type 1 apparent after seroconversion can be selected either by immune responses or by colonization of new cell types
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.69.5.3167-3170.1995