Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know?

Type 2 diabetes (T2D) had long been referred to as the “geneticist’s nightmare.” Genome-wide association studies have fully confirmed the polygenic nature of T2D, demonstrating the role of many genes in T2D risk. The increasingly busier picture of T2D genetics is quite difficult to understand for th...

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Bibliographic Details
Published in:Cell metabolism 2015-03, Vol.21 (3), p.357-368
Main Authors: Bonnefond, Amélie, Froguel, Philippe
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 2 - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - methods
Humans
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Summary:Type 2 diabetes (T2D) had long been referred to as the “geneticist’s nightmare.” Genome-wide association studies have fully confirmed the polygenic nature of T2D, demonstrating the role of many genes in T2D risk. The increasingly busier picture of T2D genetics is quite difficult to understand for the diabetes research community, which can create misunderstandings with geneticists, and can eventually limit both basic research and translational outcomes of these genetic discoveries. The present review wishes to lift the fog around genetics of T2D with the hope that it will foster integrated diabetes modeling approaches from genetic defects to personalized medicine. In this Perspective, Bonnefond and Froguel discuss the last advances in the genetics of type 2 diabetes so as to encourage integrated diabetes modeling approaches from genetic defects to personalized medicine.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2014.12.020