Relation of Doppler ultrasound synovitis versus clinical synovitis with changes in native complement component levels in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs

The complement system plays a fundamental role in mediating the activity of rheumatoid arthritis (RA). Biologic therapy can reduce native complement component levels and its activation. We aimed to study the relation of Doppler ultrasound (US) synovitis versus clinical synovitis with changes in nati...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2015-03, Vol.33 (2), p.141-145
Main Authors: Montoro Alvarez, Maria, Chong, Ong Yew, Janta, Iustina, González, Carlos, López-Longo, Javier, Monteagudo, Indalecio, Valor, Larissa, Garrido, Jesús, Lau, Ing Soo, Rosman, Azmillah, Naredo, Esperanza, Carreño, Luis
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - immunology
Biological Products - therapeutic use
Biomarkers - blood
C-Reactive Protein - metabolism
Complement Activation - drug effects
Complement System Proteins - metabolism
Cross-Sectional Studies
Female
Humans
Inflammation Mediators - blood
Male
Middle Aged
Predictive Value of Tests
Remission Induction
Severity of Illness Index
Synovial Membrane - diagnostic imaging
Synovial Membrane - drug effects
Synovial Membrane - immunology
Synovitis - diagnostic imaging
Synovitis - drug therapy
Synovitis - immunology
Time Factors
Treatment Outcome
Ultrasonography, Doppler
Young Adult
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Summary:The complement system plays a fundamental role in mediating the activity of rheumatoid arthritis (RA). Biologic therapy can reduce native complement component levels and its activation. We aimed to study the relation of Doppler ultrasound (US) synovitis versus clinical synovitis with changes in native complement component levels in RA patients on biologic therapy. This was a cross-sectional study. Ninety-seven consecutive patients with RA on biologic therapy for at least 3 months were recruited. Clinical, laboratory and Doppler US assessments were performed. The Disease Activity Score in 28 joints (DAS28), Simplified Disease Activity Index (SDAI) and a 12-joint US assessment were carried out. Synovitis was semiquantitatively scored in B-mode and power Doppler (PD) mode. A significant decrease in native complement (i.e. C3 and C4) and C-reactive protein (CRP) levels was observed. This was highly significant for C3 decrease (p
ISSN:0392-856X