Evaluation of body composition changes, epicardial adipose tissue, and serum omentin-1 levels in overt hypothyroidism

Our aim was to investigate body composition changes, epicardial adipose tissue thickness (EATT), serum omentin-1 levels, and the relationship among them along with some atherosclerosis markers in overt hypothyroidism. Twenty-eight newly diagnosed overt hypothyroid patients were evaluated before and...

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Bibliographic Details
Published in:Endocrine 2015-05, Vol.49 (1), p.196-203
Main Authors: Cerit, Ethem Turgay, Akturk, Mujde, Altinova, Alev E., Tavil, Yusuf, Ozkan, Cigdem, Yayla, Cagri, Altay, Mustafa, Demirtas, Canan, Cakir, Nuri
Format: Article
Language:English
Subjects:
Adipose Tissue - diagnostic imaging
Adult
Body Composition - physiology
Cytokines - blood
Diabetes
Endocrinology
Female
GPI-Linked Proteins - blood
Hormone Replacement Therapy
Humanities and Social Sciences
Humans
Hypothyroidism - blood
Hypothyroidism - physiopathology
Internal Medicine
Lectins - blood
Male
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original Article
Pericardium - diagnostic imaging
Prospective Studies
Science
Ultrasonography
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Summary:Our aim was to investigate body composition changes, epicardial adipose tissue thickness (EATT), serum omentin-1 levels, and the relationship among them along with some atherosclerosis markers in overt hypothyroidism. Twenty-eight newly diagnosed overt hypothyroid patients were evaluated before and after 6 months of thyroid hormone replacement therapy (THRT) and compared to the healthy subjects in this prospective longitudinal study. Body compositions were measured with dual-energy X-ray absorptiometry, and EATT was measured by echocardiography. Carotid intima-media thickness (c-IMT), flow-mediated dilatation (FMD), thyroid hormone levels, lipid parameters, high sensitive c-reactive protein, homocysteine, and omentin-1 levels were measured in all subjects. Body weight and lean body mass were higher in patients with hypothyroidism compared to euthyroid state after THRT ( p  = 0.012, 0.034, respectively). EATT was higher in patients with hypothyroidism than the control group ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-014-0460-2