Extraintestinal manifestations of inflammatory bowel disease and intestinal tuberculosis: Frequency and relation with disease phenotype

Background Extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn’s disease (CD), as well as intestinal tuberculosis (ITB) from Asia, are underreported. We, therefore, describe the prevalence of EIMs in Indian IBD and ITB patients and st...

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Published in:Indian journal of gastroenterology 2015-01, Vol.34 (1), p.43-50
Main Authors: Singh, Bikramjit, Kedia, Saurabh, Konijeti, Gauree, Mouli, Venigalla Pratap, Dhingra, Rajan, Kurrey, Lalit, Srivastava, Saurabh, Pradhan, Rajesh, Makharia, Govind, Ahuja, Vineet
Format: Article
Language:English
Subjects:
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - physiopathology
Crohn Disease - diagnosis
Crohn Disease - epidemiology
Crohn Disease - physiopathology
Gastroenterology
Hepatology
Humans
India - epidemiology
Medicine
Medicine & Public Health
Original Article
Prevalence
Retrospective Studies
Severity of Illness Index
Time Factors
Tuberculosis, Gastrointestinal - diagnosis
Tuberculosis, Gastrointestinal - epidemiology
Tuberculosis, Gastrointestinal - physiopathology
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Summary:Background Extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn’s disease (CD), as well as intestinal tuberculosis (ITB) from Asia, are underreported. We, therefore, describe the prevalence of EIMs in Indian IBD and ITB patients and study their relationship with disease extent and severity in IBD. Methods This retrospective single-center study included all IBD and ITB patients evaluated from January 2005 to July 2012. Disease profile and frequencies of arthropathies (peripheral and central) and ocular (episcleritis, iritis/uveitis), oral (aphthous stomatitis), skin (erythema nodosum, pyoderma gangrenosum, psoriasis), hepatobiliary (primary sclerosing cholangitis), and thromboembolic manifestations were analyzed. Results Of 1,652 patients (1146 UC, 303 CD, 203 ITB), frequency of any EIM was 33.2 %, 38.3 %, and 14.3 % in UC, CD, and ITB patients, respectively. Thromboembolism was more common among UC patients with pancolitis than proctitis ( p  
ISSN:0254-8860
0975-0711
DOI:10.1007/s12664-015-0538-7