Efficient approach to 2-hydroxy-2,3-dihydrofuran derivatives and its application for the synthesis of novel 4-(1H-pyrazol-4-yl)pyridazines

A highly efficient method for the synthesis of 2-hydroxy-2,3-dihydrofuran derivatives from 1,4-enediones and phenacyl pyridinium halides via a domino reaction has been developed. This is a simple and beneficial strategy for the construction of 2-hydroxy-2,3-dihydrofuran compounds from readily availa...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2015-05, Vol.13 (17), p.4976-4980
Main Authors: Ma, Jun-Rui, Shu, Wen-Ming, Zheng, Kai-Lu, Ni, Fan, Yin, Guo-Dong, Wu, An-Xin
Format: Article
Language:English
Subjects:
Crystallography, X-Ray
Furans - chemistry
Hydrocarbons, Halogenated - chemistry
Ketones - chemistry
Models, Molecular
Molecular Structure
Pyrazoles - chemical synthesis
Pyrazoles - chemistry
Pyridazines - chemical synthesis
Pyridazines - chemistry
Pyridinium Compounds - chemistry
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Summary:A highly efficient method for the synthesis of 2-hydroxy-2,3-dihydrofuran derivatives from 1,4-enediones and phenacyl pyridinium halides via a domino reaction has been developed. This is a simple and beneficial strategy for the construction of 2-hydroxy-2,3-dihydrofuran compounds from readily available starting materials under mild conditions. Moreover, the application of this reaction provides a straightforward and practical route for the synthesis of the novel 4-(1H-pyrazol-4-yl)pyridazine skeleton.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00163c