Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease

Aim The main causes of mortality from non‐alcoholic fatty liver disease (NAFLD) are cardiovascular disease (CVD) and malignancy. Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is known to be associated with CVD. However, a possible link between EPA/AA ratio and NAFLD is not well known. In t...

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Bibliographic Details
Published in:Hepatology research 2015-05, Vol.45 (5), p.533-539
Main Authors: Ishitobi, Tomokazu, Hyogo, Hideyuki, Kan, Hiromi, Hiramatsu, Akira, Arihiro, Koji, Aikata, Hiroshi, Chayama, Kazuaki
Format: Article
Language:English
Subjects:
cardiovascular disease
eicosapentaenoic acid/arachidonic acid
non-alcoholic fatty liver disease
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Summary:Aim The main causes of mortality from non‐alcoholic fatty liver disease (NAFLD) are cardiovascular disease (CVD) and malignancy. Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is known to be associated with CVD. However, a possible link between EPA/AA ratio and NAFLD is not well known. In this study, we investigated EPA/AA ratio in Japanese patients with NAFLD. Methods Two hundred and fifty‐four patients with biopsy‐proven NAFLD were retrospectively enrolled. Serum EPA/AA ratios were examined for each generation (
ISSN:1386-6346
1872-034X
DOI:10.1111/hepr.12382