Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease

Aim The main causes of mortality from non‐alcoholic fatty liver disease (NAFLD) are cardiovascular disease (CVD) and malignancy. Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is known to be associated with CVD. However, a possible link between EPA/AA ratio and NAFLD is not well known. In t...

Full description

Saved in:
Bibliographic Details
Published in:Hepatology research 2015-05, Vol.45 (5), p.533-539
Main Authors: Ishitobi, Tomokazu, Hyogo, Hideyuki, Kan, Hiromi, Hiramatsu, Akira, Arihiro, Koji, Aikata, Hiroshi, Chayama, Kazuaki
Format: Article
Language:English
Subjects:
cardiovascular disease
eicosapentaenoic acid/arachidonic acid
non-alcoholic fatty liver disease
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4272-c7483e11de60dfef83c14c84098c3d1f9212aaf9f6a85a7e827417d1dd9346853
cites cdi_FETCH-LOGICAL-c4272-c7483e11de60dfef83c14c84098c3d1f9212aaf9f6a85a7e827417d1dd9346853
container_end_page 539
container_issue 5
container_start_page 533
container_title Hepatology research
container_volume 45
creator Ishitobi, Tomokazu
Hyogo, Hideyuki
Kan, Hiromi
Hiramatsu, Akira
Arihiro, Koji
Aikata, Hiroshi
Chayama, Kazuaki
description Aim The main causes of mortality from non‐alcoholic fatty liver disease (NAFLD) are cardiovascular disease (CVD) and malignancy. Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is known to be associated with CVD. However, a possible link between EPA/AA ratio and NAFLD is not well known. In this study, we investigated EPA/AA ratio in Japanese patients with NAFLD. Methods Two hundred and fifty‐four patients with biopsy‐proven NAFLD were retrospectively enrolled. Serum EPA/AA ratios were examined for each generation (
doi_str_mv 10.1111/hepr.12382
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1675873712</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1675873712</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4272-c7483e11de60dfef83c14c84098c3d1f9212aaf9f6a85a7e827417d1dd9346853</originalsourceid><addsrcrecordid>eNp9kE9vFCEYh4mxsXX14gcwHI3JtMPAAnPUZu3aNLX1T-yNvAvvZLGzMIXZ1r37waXudo9ygcDz-4X3IeQNq49ZWSdLHNIxa7hunpEjplVT1VzcPC9nrmUluZCH5GXOv-qaqboRL8hhI1oluRRH5M_M25hhwDAChugtBevdCSSwS-9i2F3QBKOPFDIFOsSc_aJH2vtwSxc4PiAGGmKooLdxGfuS6WAcNwW4x0SdzwgZKQRHLSTn4z1ku-5h__SKHHTQZ3y92yfkx6fZ99N5dfHl7PPph4vKiqZMZZXQHBlzKGvXYae5ZcJqUbfacse6tmENQNd2EvQUFOpGCaYcc64tDvSUT8i7be-Q4t0a82hWPlvsewgY19kwqaZacVVcTsj7LWpTGTdhZ4bkV5A2htXm0bp5tG7-WS_w213verFCt0efNBeAbYEH3-PmP1VmPrv6-lRabTM-j_h7n4F0a2T549T8vDwz8-tv5x-vb87NFf8Lf5yexw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1675873712</pqid></control><display><type>article</type><title>Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Ishitobi, Tomokazu ; Hyogo, Hideyuki ; Kan, Hiromi ; Hiramatsu, Akira ; Arihiro, Koji ; Aikata, Hiroshi ; Chayama, Kazuaki</creator><creatorcontrib>Ishitobi, Tomokazu ; Hyogo, Hideyuki ; Kan, Hiromi ; Hiramatsu, Akira ; Arihiro, Koji ; Aikata, Hiroshi ; Chayama, Kazuaki</creatorcontrib><description>Aim The main causes of mortality from non‐alcoholic fatty liver disease (NAFLD) are cardiovascular disease (CVD) and malignancy. Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is known to be associated with CVD. However, a possible link between EPA/AA ratio and NAFLD is not well known. In this study, we investigated EPA/AA ratio in Japanese patients with NAFLD. Methods Two hundred and fifty‐four patients with biopsy‐proven NAFLD were retrospectively enrolled. Serum EPA/AA ratios were examined for each generation (&lt;35, 35–44, 45–54, 55–64, ≥65 years), and the differences of EPA/AA ratios were evaluated based on steatotic grades and fibrotic stages. Results EPA/AA ratio in NAFLD patients was decreased compared to that reported in age‐matched healthy controls. EPA/AA ratio, body mass index, total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol and steatotic grades in younger NAFLD patients were significantly worse than those in older NAFLD patients. Fasting glucose, hemoglobin A1c and fibrotic stages in older NAFLD patients were significantly higher than those in younger NAFLD patients. No relation was found between EPA/AA ratio and histological findings. Conclusion EPA/AA ratio was lower in NAFLD, especially in younger NAFLD patients. Considering the high mortality from CVD in NAFLD patients, low EPA/AA ratio in young age may influence the increased prevalence of CVD in their older age. EPA/AA ratio is suggested to be a possible link between NAFLD and CVD, and would become a useful marker for CVD in NAFLD.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.12382</identifier><identifier>PMID: 24976364</identifier><language>eng</language><publisher>Netherlands: Blackwell Publishing Ltd</publisher><subject>cardiovascular disease ; eicosapentaenoic acid/arachidonic acid ; non-alcoholic fatty liver disease</subject><ispartof>Hepatology research, 2015-05, Vol.45 (5), p.533-539</ispartof><rights>2014 The Japan Society of Hepatology</rights><rights>2014 The Japan Society of Hepatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4272-c7483e11de60dfef83c14c84098c3d1f9212aaf9f6a85a7e827417d1dd9346853</citedby><cites>FETCH-LOGICAL-c4272-c7483e11de60dfef83c14c84098c3d1f9212aaf9f6a85a7e827417d1dd9346853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24976364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishitobi, Tomokazu</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Kan, Hiromi</creatorcontrib><creatorcontrib>Hiramatsu, Akira</creatorcontrib><creatorcontrib>Arihiro, Koji</creatorcontrib><creatorcontrib>Aikata, Hiroshi</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><title>Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim The main causes of mortality from non‐alcoholic fatty liver disease (NAFLD) are cardiovascular disease (CVD) and malignancy. Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is known to be associated with CVD. However, a possible link between EPA/AA ratio and NAFLD is not well known. In this study, we investigated EPA/AA ratio in Japanese patients with NAFLD. Methods Two hundred and fifty‐four patients with biopsy‐proven NAFLD were retrospectively enrolled. Serum EPA/AA ratios were examined for each generation (&lt;35, 35–44, 45–54, 55–64, ≥65 years), and the differences of EPA/AA ratios were evaluated based on steatotic grades and fibrotic stages. Results EPA/AA ratio in NAFLD patients was decreased compared to that reported in age‐matched healthy controls. EPA/AA ratio, body mass index, total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol and steatotic grades in younger NAFLD patients were significantly worse than those in older NAFLD patients. Fasting glucose, hemoglobin A1c and fibrotic stages in older NAFLD patients were significantly higher than those in younger NAFLD patients. No relation was found between EPA/AA ratio and histological findings. Conclusion EPA/AA ratio was lower in NAFLD, especially in younger NAFLD patients. Considering the high mortality from CVD in NAFLD patients, low EPA/AA ratio in young age may influence the increased prevalence of CVD in their older age. EPA/AA ratio is suggested to be a possible link between NAFLD and CVD, and would become a useful marker for CVD in NAFLD.</description><subject>cardiovascular disease</subject><subject>eicosapentaenoic acid/arachidonic acid</subject><subject>non-alcoholic fatty liver disease</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kE9vFCEYh4mxsXX14gcwHI3JtMPAAnPUZu3aNLX1T-yNvAvvZLGzMIXZ1r37waXudo9ygcDz-4X3IeQNq49ZWSdLHNIxa7hunpEjplVT1VzcPC9nrmUluZCH5GXOv-qaqboRL8hhI1oluRRH5M_M25hhwDAChugtBevdCSSwS-9i2F3QBKOPFDIFOsSc_aJH2vtwSxc4PiAGGmKooLdxGfuS6WAcNwW4x0SdzwgZKQRHLSTn4z1ku-5h__SKHHTQZ3y92yfkx6fZ99N5dfHl7PPph4vKiqZMZZXQHBlzKGvXYae5ZcJqUbfacse6tmENQNd2EvQUFOpGCaYcc64tDvSUT8i7be-Q4t0a82hWPlvsewgY19kwqaZacVVcTsj7LWpTGTdhZ4bkV5A2htXm0bp5tG7-WS_w213verFCt0efNBeAbYEH3-PmP1VmPrv6-lRabTM-j_h7n4F0a2T549T8vDwz8-tv5x-vb87NFf8Lf5yexw</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Ishitobi, Tomokazu</creator><creator>Hyogo, Hideyuki</creator><creator>Kan, Hiromi</creator><creator>Hiramatsu, Akira</creator><creator>Arihiro, Koji</creator><creator>Aikata, Hiroshi</creator><creator>Chayama, Kazuaki</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease</title><author>Ishitobi, Tomokazu ; Hyogo, Hideyuki ; Kan, Hiromi ; Hiramatsu, Akira ; Arihiro, Koji ; Aikata, Hiroshi ; Chayama, Kazuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4272-c7483e11de60dfef83c14c84098c3d1f9212aaf9f6a85a7e827417d1dd9346853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>cardiovascular disease</topic><topic>eicosapentaenoic acid/arachidonic acid</topic><topic>non-alcoholic fatty liver disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishitobi, Tomokazu</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Kan, Hiromi</creatorcontrib><creatorcontrib>Hiramatsu, Akira</creatorcontrib><creatorcontrib>Arihiro, Koji</creatorcontrib><creatorcontrib>Aikata, Hiroshi</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishitobi, Tomokazu</au><au>Hyogo, Hideyuki</au><au>Kan, Hiromi</au><au>Hiramatsu, Akira</au><au>Arihiro, Koji</au><au>Aikata, Hiroshi</au><au>Chayama, Kazuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2015-05</date><risdate>2015</risdate><volume>45</volume><issue>5</issue><spage>533</spage><epage>539</epage><pages>533-539</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim The main causes of mortality from non‐alcoholic fatty liver disease (NAFLD) are cardiovascular disease (CVD) and malignancy. Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is known to be associated with CVD. However, a possible link between EPA/AA ratio and NAFLD is not well known. In this study, we investigated EPA/AA ratio in Japanese patients with NAFLD. Methods Two hundred and fifty‐four patients with biopsy‐proven NAFLD were retrospectively enrolled. Serum EPA/AA ratios were examined for each generation (&lt;35, 35–44, 45–54, 55–64, ≥65 years), and the differences of EPA/AA ratios were evaluated based on steatotic grades and fibrotic stages. Results EPA/AA ratio in NAFLD patients was decreased compared to that reported in age‐matched healthy controls. EPA/AA ratio, body mass index, total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol and steatotic grades in younger NAFLD patients were significantly worse than those in older NAFLD patients. Fasting glucose, hemoglobin A1c and fibrotic stages in older NAFLD patients were significantly higher than those in younger NAFLD patients. No relation was found between EPA/AA ratio and histological findings. Conclusion EPA/AA ratio was lower in NAFLD, especially in younger NAFLD patients. Considering the high mortality from CVD in NAFLD patients, low EPA/AA ratio in young age may influence the increased prevalence of CVD in their older age. EPA/AA ratio is suggested to be a possible link between NAFLD and CVD, and would become a useful marker for CVD in NAFLD.</abstract><cop>Netherlands</cop><pub>Blackwell Publishing Ltd</pub><pmid>24976364</pmid><doi>10.1111/hepr.12382</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1386-6346
ispartof Hepatology research, 2015-05, Vol.45 (5), p.533-539
issn 1386-6346
1872-034X
language eng
recordid cdi_proquest_miscellaneous_1675873712
source Wiley-Blackwell Read & Publish Collection
subjects cardiovascular disease
eicosapentaenoic acid/arachidonic acid
non-alcoholic fatty liver disease
title Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T18%3A06%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Eicosapentaenoic%20acid/arachidonic%20acid%20ratio%20as%20a%20possible%20link%20between%20non-alcoholic%20fatty%20liver%20disease%20and%20cardiovascular%20disease&rft.jtitle=Hepatology%20research&rft.au=Ishitobi,%20Tomokazu&rft.date=2015-05&rft.volume=45&rft.issue=5&rft.spage=533&rft.epage=539&rft.pages=533-539&rft.issn=1386-6346&rft.eissn=1872-034X&rft_id=info:doi/10.1111/hepr.12382&rft_dat=%3Cproquest_cross%3E1675873712%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4272-c7483e11de60dfef83c14c84098c3d1f9212aaf9f6a85a7e827417d1dd9346853%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1675873712&rft_id=info:pmid/24976364&rfr_iscdi=true